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This paper is based on a Senior Scholar presentation delivered at the 2020 annual meeting of the North American Society for the Psychology of Sport and Physical Activity. The paper begins with a summary of the research work completed by the author and coinvestigators in regard to the influences that significant others (parents, peers, and coaches) exert on the psychosocial well-being of individuals in sport and physical activity. In each of these three areas, illustrative research studies are summarized in a predominantly chronological order with a commentary at the end of each section that identifies unanswered questions and suggests future research directions. In the second section, four particular lessons learned by the author over the course of a scholarly career are identified and explained.