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The health and physical activity (PA) needs of people living with disabilities are underserved and understudied. This article provides an overview of research on PA and health research in people with disabilities. Research gaps and inequities are highlighted, along with their impact on advancing the fundamental rights of people with disabilities to fully participate in PA. The importance of translational PA research to disability communities is described. We provide case studies from two lines of PA and disability research that have been moved along the translational spectrum and into practice. The article concludes with three calls to action to kinesiology research and practitioners: (a) to include people with disabilities in research; (b) to advocate for adequate resources and support in alignment with equity, diversity, and inclusion efforts; and (c) to work in meaningful partnership with people with disabilities to support translational research programs that have real-world impacts.