Biomechanics is a diverse field of study founded in a vertically integrated body of knowledge, from cells to behavior, with the goal of understanding the function of biological systems using methods in mechanics. Historically, the field lies in the general domain of science, not to be isolated but well integrated with others focused on the study of movement. Using advances in technology as a conduit, specific examples of collaborative research involving biomechanics, motor development, and neuromuscular control are discussed. Challenges in the study of interface control (i.e., hypotheses focused on the neural control of movement, performance enhancement, and injury prevention) are presented in the context of the intellectual interface required among scientists to gain a new understanding of the function of biological systems.