Kinesiology is an academic discipline with a body of content that can be drawn on to support professions and to solve important public health problems. The Kansas State Physical Activity Systems Framework defines a new approach to structure the discipline. Central to the framework is the rejection of a kinesiology subdisciplinary approach and the adoption of an integrated “cell-to-society” systems approach. Each level of physical activity systems is addressed in undergraduate and graduate education and research. Supporting the framework are two research and education teams: exercise physiology and exercise behavioral science. These teams provide core integrated academic discipline content expertise and expertise for integrating professional application areas, such as public health. The framework has evolved over 20 years at Kansas State University, where today the Department of Kinesiology delivers high-quality extramurally-funded research; BS, MS, MPH, and PhD programs; and outreach in a cost-effective manner.