Chronic disease is a leading cause of morbidity and mortality in the United States. One-half of U.S. adults have at least one chronic disease condition and 25% have multiple chronic conditions that can lead to a restriction in an ability to do basic daily living activities. Low-income adults have a high incidence of chronic disease that increases with aging due to ongoing psychological stress, higher risk exposure, less healthy living conditions, and limited access to health services. Community-based wellness programs, in collaboration with academic institutions, can serve this population by providing access to health services, quality educational and activity-based experiences, and continual assessment and support. Using a multidisciplinary approach, the expertise of numerous faculty, students, and staff can be used to help mitigate a myriad of health conditions presented by this population. This article shares one university’s creation, development, and delivery of an on-campus, multidisciplinary community wellness program for low-income adults.