The Effect of Neurodegeneration on Visuomotor Behavior in Alzheimer’s Disease and Parkinson’s Disease

in Motor Control
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The early stages of neurodegenerative disorders such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) involve deterioration of specific (visuo)motor functions. The aim of the current study was to investigate differences in visuomotor behavior between age-matched groups of 17 patients with AD, 17 patients with PD, and 20 healthy control subjects across three eye-hand-coordination tasks of different cognitive complexity. In two of three tasks, timing and execution parameters of eyes and hand significantly differed between groups. Timing and execution parameters of the eyes and hands could potentially give a quantitative description of disease specific deficits in the spatial and temporal domains and may serve as a tool to monitor disease progression in AD and PD populations.

de Boer, van der Steen and Pel are with the Department of Neuroscience, Erasmus MC, and Vestibular and Ocular Motor Research Group, Rotterdam, The Netherlands. Mattace-Raso is with Department of Geriatrics, Erasmus MC, Rotterdam, The Netherlands. Boon is with the Department of Neurology, Erasmus MC, Rotterdam, The Netherlands.

Address author correspondence to Casper de Boer at