Brain Activation Changes During Balance- and Attention-Demanding Tasks in Middle- and Older-Aged Adults With Multiple Sclerosis

in Motor Control

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Manuel E. Hernandez University of Illinois at Urbana-Champaign

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Erin O’Donnell University of Illinois at Urbana-Champaign

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Gioella Chaparro University of Illinois at Urbana-Champaign

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Roee Holtzer Yeshiva University

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Meltem Izzetoglu Villanova University

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Brian M. Sandroff The University of Alabama at Birmingham

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Robert W. Motl The University of Alabama at Birmingham

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DOI:
https://doi.org/10.1123/mc.2018-0044
Keywords:
cognitive control; divided attention; gait
In Print:
Volume 23: Issue 4
Page Range:
498–517
Restricted access

Functional near-infrared spectroscopy was used to evaluate prefrontal cortex activation differences between older adults with multiple sclerosis (MS) and healthy older adults (HOA) during the performance of a balance- and attention-demanding motor task. Ten older adults with MS and 12 HOA underwent functional near-infrared spectroscopy recording while talking, virtual beam walking, or virtual beam walking while talking on a self-paced treadmill. The MS group demonstrated smaller increases in prefrontal cortex oxygenation levels than HOA during virtual beam walking while talking than talking tasks. These findings indicate a decreased ability to allocate additional attentional resources in challenging walking conditions among MS compared with HOA. This study is the first to investigate brain activation dynamics during the performance of balance- and attention-demanding motor tasks in persons with MS.

Hernandez, O’Donnell, and Chaparro are with the University of Illinois at Urbana-Champaign, Urbana, IL. Holtzer is with the Albert Einstein College of Medicine, Yeshiva University, Bronx, NY. Izzetoglu is with Villanova University, Villanova, PA. Sandroff and Motl are with The University of Alabama at Birmingham, Birmingham, AL.

Hernandez (mhernand@illinois.edu) is corresponding author.
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