Augmented Muscle Vasodilatory Responses in Obese Children with Glu27 β2-Adrenoceptor Polymorphism

in Pediatric Exercise Science
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This study examined forearm vasodilatation during mental challenge and exercise in 72 obese children (OC; age = 10 ± 0.1 years) homozygous with polymorphism in the allele 27 of the β2-adrenoceptors: Gln27 (n = 61) and Glu27 (n = 11). Forearm blood flow was recorded during 3 min of each using the Stroop color-word test (MS) and handgrip isometric exercise. Baseline hemodynamic and vascular measurements were similar. During the MS, peak forearm vascular conductance was significantly greater in group Glu27 (Δ = 0.35 ± 0.4 vs. 0.12 ± 0.1 units, respectively, p = .042). Similar results were found during exercise (Δ = 0.64 ± 0.1 vs. 0.13 ± 0.1 units, respectively, p = .035). Glu27 OC increased muscle vasodilatory responsiveness upon the MS and exercise.

da Silva, Ribeiro, Nicolau, Frazzetto, Guazzelli, Halpern, and Villares are with the Dept. of Endocrinology, University of São Paulo, São Paulo, Brazil. Trombetta and Matos are with the Heart Institute (InCor), Medical School, University of São Paulo, São Paulo, Brazil. Negrão is with the Heart Institute (InCor), Medical School, University of São Paulo, São Paulo, Brazil and the School of Physical Education and Sport, University of São Paulo, São Paulo, Brazil.