No studies to date have evaluated the relationship between exercise and microvascular function in youth with type 1 diabetes mellitus (T1DM). Twenty-nine complication free children and adolescents with T1DM were assessed for skin microvascular reactivity, aerobic fitness (VO2peak) and physical activity. VO2peak but not physical activity was significantly and independently associated with maximal hyperemia of the skin microcirculation (p < .01). No significant associations were found between venoarte-riolar reflex (VAR) vasoconstriction and VO2peak or physical activity. Aerobic fitness may be an important indicator or mediator of effective microvascular endothelial function in youth with T1DM.
Roche is with the Dept. of Sport and Exercise Science, Liverpool Hope University, Liverpool, L16 9JD, UK. Edmunds is with the School of Human Sciences, St. Mary’s University College, Twickenham, TW1 4SX, UK. Cable and Stratton are with the Research Institute for Sport and Exercise Sciences (RISES), Liverpool John Moores University, Liverpool, L2 2ET, UK. Didi is with the Royal Liverpool Children’s Hospital, Liverpool, L12 2AP, UK.