Exercise Leukocyte Profiles in Healthy, Type 1 Diabetic, Overweight, and Asthmatic Children

in Pediatric Exercise Science
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Leukocytosis contributes to exercise-induced immune modulation, which is a mechanism of cardiovascular protection. However, this process is poorly defined in children. We therefore measured leukocytes in 45 healthy, 18 overweight, 16 type 1 diabetic, and 8 asthmatic children at pre, end-, and 30-min postexercise (30-min intermittent or 6-min continuous). In all groups, total leukocytes, neutrophils, lymphocytes, and monocytes increased at end-exercise, but returned to baseline by 30-min postexercise, including neutrophils, previously reported to remain elevated for at least some exercise formats. This highly preserved pattern indicates the importance of the adaptive response to physical stress across multiple health conditions.

Rosa and Galassetti are with the Dept. of Pharmacology, School of Medicine, University of California, Irvine, CA 92697. Schwindt, Oliver, Leu, and Flores are with the Institute for Clinical Translational Science, Dept. of Pediatrics, University of California, Irvine, CA 92868.