Regular physical activity may play a protective role against cardiovascular disease in adults, and paraoxonase activity may serve to mediate this effect. This study compared paraoxonase activity and that of other antioxidative agents in adolescent athletes compared with inactive youth. Paraoxonase level was 177.32 ± 100.10 (U/L) in children with regular physical activity and 98.11 ± 40.92 (U/L) in the control group (P < 0.0001). The levels of total antioxidative capacity, total oxidative status, oxidative stress index, and lipid hydroperoxide were significantly higher in the athlete group compared with controls (P < 0.0001). Paraoxonase activity was found to be greater in adolescent athletes, suggesting that regular exercise might provide a cardio-protective effect by this means.
Cakmak, Zeyrek, and Atas are with the Dept. of Pediatrics, Harran University Faculty of Medicine, Sanliurfa, Turkey. Erel is with the Dept. of Clinical Chemistry, Harran University Faculty of Medicine, Sanliurfa, Turkey.