The relationship between peak aerobic fitness (peakVO2) and plasma leptin was assessed in 25 normal (BMI < 85th %tile) and 25 overweight (BMI > 85th %tile) youth, ages 7–17 years. In the overall analysis peakVO2 was related to leptin when expressed in mL/kg/min (R2 = .516, p < .0001), or as ml/kgFFM/min (R2 = .127, p = .01). The relationships between peakVO2 and leptin were no longer significant when percent bodyfat was added to the models. In subanalyses by weight groups, peakVO2: leptin relationships were not evident for normal weight, but remained for overweight youth. In conclusion the relationship between aerobic fitness and leptin in youth is dependent upon weight status.
Hosick and McMurray are with the Dept. of EXSS, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-8700. Cooper is with the Pediatric Exercise Research Center, Dept. of Pediatrics, University Children’s Hospital, University of California, Irvine, Irvine, CA.