Aerobic Training Suppresses Exercise-Induced Lipid Peroxidation and Inflammation in Overweight/Obese Adolescent Girls

in Pediatric Exercise Science
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  • 1 University of Rennes 2
  • 2 University of Balamand
  • 3 Dynamics of Human Revolution
  • 4 University of Liège
  • 5 University of Rennes
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This study aimed to determine whether aerobic training could reduce lipid peroxidation and inflammation at rest and after maximal exhaustive exercise in overweight/obese adolescent girls. Thirty-nine adolescent girls (14-19 years old) were classified as nonobese or overweight/obese and then randomly assigned to either the nontrained or trained group (12-week multivariate aerobic training program). Measurements at the beginning of the experiment and at 3 months consisted of body composition, aerobic fitness (VO2peak) and the following blood assays: pre- and postexercise lipid peroxidation (15F2a-isoprostanes [F2-Isop], lipid hydroperoxide [ROOH], oxidized LDL [ox-LDL]) and inflammation (myeloperoxidase [MPO]) markers. In the overweight/obese group, the training program significantly increased their fat-free mass (FFM) and decreased their percentage of fat mass (%FM) and hip circumference but did not modify their VO2peak. Conversely, in the nontrained overweight/obese group, weight and %FM increased, and VO2peak decreased, during the same period. Training also prevented exercise-induced lipid peroxidation and/or inflammation in overweight/obese girls (F2-Isop, ROOH, ox-LDL, MPO). In addition, in the trained overweight/obese group, exercise-induced changes in ROOH, ox-LDL and F2-Isop were correlated with improvements in anthropometric parameters (waist-to-hip ratio, %FM and FFM). In conclusion aerobic training increased tolerance to exercise-induced oxidative stress in overweight/obese adolescent girls partly as a result of improved body composition.

Youssef, Groussard, Lemoine-Morel, Cillard, and Delamarche are with Laboratory of Movement, Sport, and Health (M2S), University of Rennes 2, Rennes, France. Pincemail is with the Dept. of Cardiovascular Surgery, University of Liege, Liege, Belgium. Jacob, Moussa, and Fazah are with the Laboratory of Physiology and Biomechanics of Motor Performance, University of Balamand, Balamand, Lebanon. Pineau is with the L’UPR 2147, Dynamics of Human Evolution, Paris, France.

Address author correspondence to Carole Groussard at carole. groussard@univ-rennes2.fr.