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The purpose of this study was to assess the criterion validity of existing accelerometer-based energy expenditure (EE) prediction equations among children with chronic conditions, and to develop new prediction equations. Children with congenital heart disease (CHD), cystic fibrosis (CF), dermatomyositis (JDM), juvenile arthritis (JA), inherited muscle disease (IMD), and hemophilia (HE) completed 7 tasks while EE was measured using indirect calorimetry with counts determined by accelerometer. Agreement between predicted EE and measured EE was assessed. Disease-specific equations and cut points were developed and cross-validated. In total, 196 subjects participated. One participant dropped out before testing due to time constraints, while 15 CHD, 32 CF, 31 JDM, 31 JA, 30 IMD, 28 HE, and 29 healthy controls completed the study. Agreement between predicted and measured EE varied across disease group and ranged from (ICC) .13–.46. Disease-specific prediction equations exhibited a range of results (ICC .62–.88) (SE 0.45–0.78). In conclusion, poor agreement was demonstrated using current prediction equations in children with chronic conditions. Disease-specific equations and cut points were developed.
Stephens, Pullenayegum, Abad, and Ignas are with Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada. Takken is with the Child Development & Exercise Center, UMC Utrecht, Utrecht, The Netherlands. Esliger is with the School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, United Kingdom. Beyene is with McMaster University, Hamilton, Canada. Tremblay is with the Children’s Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada. Schneiderman is with the Department of Physiology and Experimental Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada. Biggar is with Bloorview Children’s Hospital, Toronto, Ontario, Canada. Longmuir is with the Healthy Active Living and Obesity Research Group, Children’s Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada. McCrindle is with the Department of Cardiology, The Hospital for Sick Children, Toronto, Ontario, Canada. Van Der Net is with the Child Development and Exercise Center, Division of Pediatrics, University Children’s Hospital and Medical Center, Untrecht, The Netherlands. Feldman is with the Department of Rheumatology, The Hospital for Sick Children, Toronto, Ontario, Canada.