Impact of a School-Based Intervention Protocol—ACORDA Project—On Adipokines in an Overweight and Obese Pediatric Population

in Pediatric Exercise Science
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There are few reliable studies assessing the effect of physical exercise (PE) on adipokines levels at young ages. Our objective was to study the effects of regular PE on plasma adipokines in pediatric overweight and obesity.


117 overweight and obese children and adolescents (47% females; 10.2 years) participated in an 8-month longitudinal study divided in two groups: PE group (n = 80), engaged in an after-school PE program; control group (n = 37), with no PE program. Plasma lipids, C-reactive protein (CRP), adiponectin, resistin, leptin, IL-6, IL-1beta, TNF-alpha, insulin and glucose levels were determined.


contrarily to the control group, the PE group presented reductions in body mass index z-score (BMIzsc) and body fat percentage that were accompanied by an improvement in lipid profile and insulin resistance, a reduction in CRP and TNF-alpha and an increase in adiponectin levels. The reductions in BMIzsc were inversely correlated with changes in adiponectin (r=−0.329, p = .003) and positively correlated with changes in percentage body fat (r = .262, p = .032), triglycerides (r = .228, p = .042) and leptin (r = .285, p = .010).


Moderate reductions in adiposity improve proinflammatory status in obese children and adolescents. A more substantial reduction in BMIzsc was associated with a greater increment in adiponectin and reduction in leptin.

Nascimento, Alves, Coimbra, Catarino, Bronze-da-Rocha, Costa are with the Dept. of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal. Medeiros and Silva, Aires are with the CIAFEL — Research Centre in Physical Activity, Health and Leisure, University of Porto, Porto, Portugal. Rocha-Pereira is with the Dept. of Health Science Research Centre, University of Beira Interior, Covilhã, Portugal. Seabra is with the Faculty of Sports, University of Porto, Porto, Portugal. Mota is with the Research Centre in Physical Activity Health and Leisure, FADEUP, Porto, Portugal. Ferreira Mansilha is with the Dept. of Childhood and Adolescence Department of CMIN, Oporto Hospital Centre, Porto, Portugal. Rêgo is with the Center for Research in Health Technologies and Information Systems, University of Porto. Santos-Silva and Belo are with the Dept. of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal.

Address author correspondence to Henrique Nascimento at