The stress experiences and their impact upon the daily lives and mental well-being of English Premier League professional (soccer) football coaches were explored using an in-depth qualitative design. Eight participants were interviewed using a semi-structured approach with thematic and causal network analysis revealing that (a) a range of contextually dependent demands were experienced and interpreted in relation to their situational properties; (b) many demands were appraised and emotionally responded to in a negative manner; (c) a range of coping strategies were adopted to cope with stress experiences, with many reported as ineffective; and (d) stress experiences often led to negative implications for their daily lives and eudaimonic and hedonic well-being. Positive adaptations to some demands experienced were reported and augmented perceptions of mental well-being. The findings of this study make a novel and significant contribution to understanding the interrelationships between the principal components of the stress process and the prospective links between stress and mental well-being.