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Maria Francesca Piacentini, Oliver C. Witard, Cajsa Tonoli, Sarah R. Jackman, James E. Turner, Arie K. Kies, Asker E. Jeukendrup, Kevin D. Tipton, and Romain Meeusen

Context:

Monitoring mood state is a useful tool for avoiding nonfunctional overreaching. Brain-derived neurotrophic factor (BDNF) is implicated in stress-related mood disorders.

Purpose:

To investigate the impact of intensified training-induced mood disturbance on plasma BDNF concentrations at rest and in response to exercise.

Methods:

Eight cyclists performed 1 wk of normal (NT), 1 wk of intensified (INT), and 1 wk of recovery (REC) training. Fasted blood samples were collected before and after exercise on day 7 of each training week and analyzed for plasma BDNF and cortisol concentrations. A 24-item Profile of Mood State questionnaire was administered on day 7 of each training week, and global mood score (GMS) was calculated.

Results:

Time-trial performance was impaired during INT (P = .01) and REC (P = .02) compared with NT. Basal plasma cortisol (NT = 153 ± 16 ng/mL, INT = 130 ± 11 ng/mL, REC = 150 ± 14 ng/ml) and BDNF (NT = 484 ± 122 pg/mL, INT = 488 ± 122 pg/mL, REC = 383 ± 56 pg/mL) concentrations were similar between training conditions. Likewise, similar exercise-induced increases in cortisol and BDNF concentrations were observed between training conditions. GMS was 32% greater during INT vs NT (P < .001).

Conclusions:

Consistent with a state of functional overreaching (FOR), impairments in performance and mood state with INT were restored after 1 wk of REC. These results support evidence for mood changes before plasma BDNF concentrations as a biochemical marker of FOR and that cortisol is not a useful marker for predicting FOR.

Open access

James A. Betts, Javier T. Gonzalez, Louise M. Burke, Graeme L. Close, Ina Garthe, Lewis J. James, Asker E. Jeukendrup, James P. Morton, David C. Nieman, Peter Peeling, Stuart M. Phillips, Trent Stellingwerff, Luc J.C. van Loon, Clyde Williams, Kathleen Woolf, Ron Maughan, and Greg Atkinson