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Sitting Time, Physical Activity, and Cardiorespiratory Fitness: Cooper Center Longitudinal Study Cohort

Carolyn E. Barlow, Kerem Shuval, Bijal A. Balasubramanian, Darla E. Kendzor, and Kelley Pettee Gabriel

Background:

Prolonged sitting time is associated with numerous health outcomes; however, the role of cardiorespiratory fitness (CRF) in these relationships is largely unexplored. The cross-sectional association between reported sitting time and measured CRF was examined in a large study of healthy men and women.

Methods:

The analytic sample included 4658 men and 1737 women enrolled in the Cooper Center Longitudinal Study. Unadjusted and adjusted multivariable linear regression models were constructed to examine the association between sitting time and CRF, stratified by sex and meeting (or not) meeting physical activity (PA) guidelines.

Results:

In men, CRF was not associated with sitting time after adjustment for potential confounders. In contrast, for women, after adjustment there was a significant association between increased sitting time and lower CRF (P for trend <.001). When stratified by meeting or not meeting PA guidelines, there was no association between sitting time and CRF in men. In women, this relationship was statistically significant regardless of PA category (both P for trend < .05).

Conclusions:

These results suggest that the association between sitting time and CRF varies by sex. Further, meeting PA guidelines does not appear to modify this relation in either sex.

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Muscular Fitness and All-Cause Mortality: Prospective Observations

Shannon J. FitzGerald, Carolyn E. Barlow, James B. Kampert, James R. Morrow Jr., Allen W. Jackson, and Steven N. Blair

Background:

The beneficial effects of cardiorespiratory fitness on mortality are well known; however, the relation of muscular fitness, specifically muscular strength and endurance, to mortality risk has not been thoroughly examined. The purpose of the current study is to determine if a dose-response relation exists between muscular fitness and mortality after controlling for factors such as age and cardiorespiratory fitness.

Methods:

The study included 9105 men and women, 20–82 years of age, in the Aerobics Center Longitudinal Study who have completed at least one medical examination at the Cooper Clinic in Dallas, TX between 1981 and 1989. The exam included a muscular fitness assessment, based on 1-min sit-up and 1-repetition maximal leg and bench press scores, and a maximal treadmill test. We conducted mortality follow-up through 1996 primarily using the National Death Index, with a total follow-up of 106,046 person-years. All-cause mortality rates were examined across low, moderate, and high muscular fitness strata.

Results:

Mortality was confirmed in 194 of 9105 participants (2.1%). The age- and sex-adjusted mortality rate of those in the lowest muscular fitness category was higher than that of those in the moderate fitness category (26.8 vs. 15.3 per 10,000 person-years, respectively). Those in the high fitness category had a mortality rate of 20.6 per 10,000 person-years. The moderate and high muscular fitness groups had relative risks of 0.64 (95%CI = 0.44–0.93) and 0.80 (95%CI = 0.49–1.31), adjusting for age, health status, body mass index, cigarette smoking, and cardio-respiratory fitness when compared with the low muscular fitness group.

Conclusions:

Mortality rates were lower for individuals with moderate/high muscular fitness compared to individuals with low muscular fitness. These findings warrant further research to confirm the apparent threshold effect between low and moderate/high muscular fitness and all-cause mortality.

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Pandemic-Related Life Events and Physical Inactivity During COVID-19 Among Israeli Adults: The Smoking and Lifestyles in Israel Study

Kerem Shuval, Mahmoud Qadan, David Leonard, Carolyn E. Barlow, Jeffrey Drope, Loretta DiPietro, Reid Oetjen, Qing Li, and Laura F. DeFina

Background: Public health measures to contain the COVID-19 pandemic have led to disruptions in daily life, such as job loss and changes in activity. The present study examines the relationship between pandemic-related life events and disuse (prolonged sitting coupled with inactivity) among adults. Methods: A cross-sectional study of 4084 adults in Israel (September 2020). The primary independent variables were pandemic-related life events, such as job loss. The primary dependent variable was disuse as measured by the Rapid Assessment Disuse Index (RADI). The RADI was examined continuously and dichotomously as a low RADI score (<26: yes/no). Results: Linear regression indicated that experiencing a major life event during the pandemic was associated with lower RADI scores (−1.03; 95% confidence interval, −1.47 to −0.60). Similarly, logistic regression revealed that those experiencing a major life event had 1.22 (95% confidence interval, 1.07 to 1.40) times greater odds for low RADI scores in comparison to those not experiencing an event. Conclusions: Experiencing pandemic-related major life events was linked to less sitting time and increased activity levels among Israeli adults. Future research should examine underlying mechanisms explaining this relationship to facilitate the design and implementation of targeted interventions.