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William H. Gurton, Steve H. Faulkner, and Ruth M. James

lactate. 1 Extracellular buffering mechanisms act to remove these H + from the skeletal muscle cell, but once production rates overwhelm neutralization reactions, the excess H + contribute toward decreasing intramuscular pH. 2 Exercise-induced acidosis inhibits glycolytic energy production and

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Alannah K.A. McKay, Peter Peeling, Martyn J. Binnie, Paul S.R. Goods, Marc Sim, Rebecca Cross, and Jason Siegler

The ingestion of sodium bicarbonate (NaHCO 3 ) is well accepted as an efficacious ergogenic aid to improve short-duration, high-intensity exercise performance. 1 The exogenous intake of NaHCO 3 acts as an extracellular buffer, raising blood pH and bicarbonate (HCO 3 − ) concentrations and

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Jason C. Siegler, Amelia J. Carr, William T. Jardine, Lilia Convit, Rebecca Cross, Dale Chapman, Louise M. Burke, and Megan Ross

influencing the individual responses to extracellular buffering agents . Frontiers in Nutrition, 5, 35 . https://doi.org/10.3389/fnut.2018.00035 10.3389/fnut.2018.00035 Kowalchuk , J.M. , Maltais , S.A. , Yamaji , K. , & Hughson , R.L. ( 1989 ). The effect of citrate loading on exercise

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Charles S. Urwin, Rodney J. Snow, Dominique Condo, Rhiannon M.J. Snipe, Glenn D. Wadley, Lilia Convit, and Amelia J. Carr

, 44 ( Suppl. 1 ), 79 – 85 . https://doi.org/10.1007/s40279-014-0153-2 10.1007/s40279-014-0153-2 de Oliveira , L.F. , Dolan , E. , Swinton , P.A. , Durkalec-Michalski , K. , Artioli , G.G. , McNaughton , L.R. , & Saunders , B. ( 2021 ). Extracellular buffering supplements to improve

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Tue A.H. Lassen, Lars Lindstrøm, Simon Lønbro, and Klavs Madsen

 al., 2004 ) and in line with the suggested effect for SBS in improving extracellular buffering and subsequently increasing intramuscular pH during the exercise period ( Hargreaves & Spriet, 2020 ). In order to investigate the effect of SBS on performance, one needs to consider the large individual variation

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Rodrigo dos Santos Guimarães, Alcides Correa de Morais Junior, Raquel Machado Schincaglia, Bryan Saunders, Gustavo Duarte Pimentel, and João Felipe Mota

, P.H.L. , Oliveira , L.F. , McNaughton , L.R. , & Saunders , B. ( 2018 ). Time to optimize supplementation: modifying factors influencing the individual responses to extracellular buffering agents . Frontiers in Nutrition, 5 ( 5 ), 35 . PubMed ID: 29868599 doi:10.3389/fnut.2018.00035 10

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Rebecca L. Jones, Trent Stellingwerff, Paul Swinton, Guilherme Giannini Artioli, Bryan Saunders, and Craig Sale

.R. , & Saunders , B. ( 2018 ). Time to optimize supplementation: Modifying factors influencing the individual responses to extracellular buffering agents . Frontiers in Nutrition, 5, 35 . https://doi.org/10.3389/fnut.2018.00035 10.3389/fnut.2018.00035 Ingham , S.A. , Fudge , B.W. , Pringle , J

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Charles S. Urwin, Rodney J. Snow, Dominique Condo, Rhiannon Snipe, Glenn D. Wadley, and Amelia J. Carr

factors influencing the individual responses to extracellular buffering agents . Frontiers in Nutrition, 5 ( 1 ), 35 . PubMed ID: 29868599 doi:10.3389/fnut.2018.00035 10.3389/fnut.2018.00035 Hilton , N. , Leach , N. , Sparks , A. , Gough , L. , Craig , M. , Deb , S. , & McNaughton , L

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Ricardo Augusto Silva de Souza, André Guedes da Silva, Magda Ferreira de Souza, Liliana Kataryne Ferreira Souza, Hamilton Roschel, Sandro Fernandes da Silva, and Bryan Saunders

.2017-0273 Heibel , A.B. , Perim , P.H.L. , Oliveira , L.F. , McNaughton , L.R. , & Saunders , B. ( 2018 ). Time to optimize supplementation: Modifying factors influencing the individual responses to extracellular buffering agents . Frontiers in Nutrition, 5, 35 . PubMed ID: 29868599 doi

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Graeme L. Close, Andreas M. Kasper, Neil P. Walsh, and Ronald J. Maughan

, 18 . https://doi.org/10.1186/s12970-017-0173-z 10.1186/s12970-017-0173-z Lancha Junior , A.H. , de Salles Painelli , V. , Saunders , B. , & Artioli , G.G. ( 2015 ). Nutritional strategies to modulate intracellular and extracellular buffering capacity during high-intensity exercise . Sports