According to the cross-bridge theory, the steady-state isometric force of a muscle is given by the amount of actin–myosin filament overlap. However, it has been known for more than half a century that steady-state forces depend crucially on contractile history. Here, we examine history-dependent steady-state force production in view of the cross-bridge theory, available experimental evidence, and existing explanations for this phenomenon. This is done on various structural levels, ranging from the intact muscle to the myofibrillar and isolated contractile protein level, so that advantages and limitations of the various preparations can be fully exploited and overcome. Based on experimental evidence, we conclude that steady-state force following active muscle stretching is enhanced, and this enhancement has a passive and an active component. The active component is associated with the cross-bridge kinetics, and the passive component is associated with a calcium-dependent increase in titin stiffness.
Search Results
Mysteries of Muscle Contraction
Walter Herzog, Timothy R. Leonard, Venus Joumaa, and Ashi Mehta
Multifidus Denervation After Radiofrequency Ablation of the Medial Nerve Alters the Biomechanics of the Spine—A Computational Study
Faris A. Almalki and Daniel H. Cortes
measurement and normative values . Spine . 2001 ; 26 ( 1 ): 53 – 60 . PubMed ID: 11148646 doi:10.1097/00007632-200101010-00011 25. Chaqour B , Goppelt-Struebe M . Mechanical regulation of the Cyr61/CCN1 and CTGF/CCN2 proteins . FEBS J . 2006 ; 273 ( 16 ): 3639 – 3649 . PubMed ID: 16856934 doi:10
Poststretch Isometric Contractions of the Hamstrings: Just a Brief Stretch to Achieve Supramaximal Isometric Force
Neil Chapman, John William Whitting, Suzanne Broadbent, Zachary Crowley-McHattan, and Rudi Meir
preactivation developed in the current study may be great enough to have influenced the magnitude of rFE by lengthening of the contractile element during the joint rotation. 50 , 53 , 55 Lengthening is likely to have influenced tension in the giant protein titin, and therefore the capacity of titin to
Osteoarthritic Tibiofemoral Joint Contact Characteristics During Weightbearing With Arch-Supported and Standalone Lateral Wedge Insoles
Calvin T.F. Tse, Michael B. Ryan, Natasha M. Krowchuk, Alexander Scott, and Michael A. Hunt
.1016/j.joca.2015.02.005 6. Erhart-Hledik JC , Chehab EF , Asay JL , Favre J , Chu CR , Andriacchi TP . Longitudinal changes in tibial and femoral cartilage thickness are associated with baseline ambulatory kinetics and cartilage oligomeric matrix protein (COMP) measures in an
Concussion History Moderates Trunk Motion and Lower Extremity Biomechanical Relationships During Jump Landing and Cutting
Kayla M. Kowalczyk, Eric J. Shumski, Julianne D. Schmidt, and Robert C. Lynall
. 2021 ; 16 ( 1 ): 682 . doi: 10.26603/001C.18682 3. Howard EE , Pasiakos SM , Fussell MA , Rodriguez NR . Skeletal muscle disuse atrophy and the rehabilitative role of protein in recovery from musculoskeletal injury . Adv Nutr . 2020 ; 11 ( 4 ): 989 – 1001 . doi: 10.1093/ADVANCES/NMAA015 4
A Narrative Review of Personalized Musculoskeletal Modeling Using the Physiome and Musculoskeletal Atlas Projects
Justin Fernandez, Vickie Shim, Marco Schneider, Julie Choisne, Geoff Handsfield, Ted Yeung, Ju Zhang, Peter Hunter, and Thor Besier
common coordinate systems for embedding autonomic nervous system data in a way that would allow cross-species comparisons, that is, any aspect of the tissue material properties (such as protein expression levels) could be compared at the same anatomical location across for example mouse, rat, pig, and
Regulating Movement Frequency and Speed: Implications for Lumbar Spine Load Management Strategies Demonstrated Using an In Vitro Porcine Model
Jackie D. Zehr, Jessa M. Buchman-Pearle, Tyson A.C. Beach, Chad E. Gooyers, and Jack P. Callaghan
shear deformation stimulates proteoglycan and protein biosynthesis in bovine cartilage explants . Arch Biochem Biophys . 2001 ; 395 ( 1 ): 41 – 48 . PubMed ID: 11673864 doi:10.1006/abbi.2001.2543 11673864 10.1006/abbi.2001.2543 45. Aasa U , Bengtsson V , Bergland L , Öhberg F . Variability
Differences in Knee Extensors’ Muscle–Tendon Unit Passive Stiffness, Architecture, and Force Production in Competitive Cyclists Versus Runners
Leonardo Cesanelli, Sigitas Kamandulis, Nerijus Eimantas, and Danguole Satkunskiene
of proteins and extracellular tissues that readily adapt to the imposed load may explain structural alterations in architectural features of the muscle, in the resistance to passive MTU lengthening, and its active force production. 4 , 7 , 8 , 20 In this regard, cycling training as a concentric
Force–Time Characteristics of Repeated Bouts of Depth Jumps and the Effects of Compression Garments
Freddy Brown, Matt Hill, Derek Renshaw, and Jason Tallis
CA , et al . Resistance training‐induced changes in integrated myofibrillar protein synthesis are related to hypertrophy only after attenuation of muscle damage . J Physiol . 2016 ; 594 ( 18 ): 5209 – 5222 . doi: 10.1113/JP272472 32. Hortobagyi T , Hill JP , Houmard JA , Fraser DD
Chronic Adaptions in Quadriceps Fascicle Mechanics Are Related to Altered Knee Biomechanics After Anterior Cruciate Ligament Reconstruction
McKenzie S. White, Lucia M. Mancini, Luke Stoneback, Riann M. Palmieri-Smith, and Lindsey K. Lepley
, Franz JR , Hackney AC , et al . Lesser lower extremity mechanical loading associates with a greater increase in serum cartilage oligomeric matrix protein following walking in individuals with anterior cruciate ligament reconstruction . Clin Biomech . 2018 ; 60 : 13 – 19 . doi: 10.1016/j
