The prevalence of arthritis in aging populations continues to rapidly grow. Research has highlighted 2 principal risk factors for progression of arthritis-related biopsychosocial symptoms: age and physical inactivity. This study examined the relationship between and within physical activity and age on biopsychosocial symptoms of arthritis in adults (age ≥ 30 yr). Hierarchical, multiple-regression analyses were conducted on the Canadian Community Health Survey (Cycle 4.2, 2009–2010, N = 19,103). Results revealed that more-active adults had significantly fewer symptoms (physical unstd. B = −.23, p ≤ .001; pyschosocial unstd. B = −.51, p ≤ .001). In addition, as age increased, physical symptoms intensified and psychosocial symptoms tapered (physical unstd. B = .24, p ≤ .001; psychosocial unstd. B = −.45, p ≤ .001). Inactive older adults had the highest level of physical symptoms, while inactive younger adults had the highest level of psychosocial symptoms (p ≤ .001). Findings highlight the need to target physical activity interventions to specific age cohorts and particular biopsychosocial symptomologies.