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Peter Peeling, Martyn J. Binnie, Paul S.R. Goods, Marc Sim and Louise M. Burke

buffering capacity to support high rates of anaerobic glycolysis ( Kreider, 1999 ); improvement of myocardial contractility leading to increased cardiac efficiency ( Kreider et al., 1992 ); and an increased erythrocyte 2,3 diphosphoglycerate (2,3 DPG) concentration, leading to a reduced affinity of oxygen