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Ricardo J.S. Costa, Beat Knechtle, Mark Tarnopolsky and Martin D. Hoffman

fuel substrate during low- and moderate-intensity running, and/or when endogenous muscle glycogen stores become depleted. It is well established that fat oxidation, at a given running intensity, can be upregulated by appropriate training, or in response to dietary carbohydrate and fat manipulations

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Ronald J. Maughan, Louise M. Burke, Jiri Dvorak, D. Enette Larson-Meyer, Peter Peeling, Stuart M. Phillips, Eric S. Rawson, Neil P. Walsh, Ina Garthe, Hans Geyer, Romain Meeusen, Luc van Loon, Susan M. Shirreffs, Lawrence L. Spriet, Mark Stuart, Alan Vernec, Kevin Currell, Vidya M. Ali, Richard G.M. Budgett, Arne Ljungqvist, Margo Mountjoy, Yannis Pitsiladis, Torbjørn Soligard, Uğur Erdener and Lars Engebretsen

fuel substrate ( Stellingwerff & Cox, 2014 ), to support the immune system ( Peake et al., 2017 ), or to improve bioavailability of other supplements (e.g., creatine; Steenge et al., 2000 ). Similarly, creatine supplementation may directly enhance performance in strength and power events, and can