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  • Author: Jaci L. VanHeest x
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Jaci L. VanHeest, Jim Stoppani, Tim P. Scheett, Valerie Collins, Melissa Roti, Jeffrey Anderson, George J. Allen, Jay Hoffman, William J. Kraemer, and Carl M. Maresh

Objective:

To determine the effects of Vicoprofen® and ibuprofen on aerobic performance, agility, and pain after exercise-induced muscle damage.

Design:

Double-blind randomized, placebo-controlled, repeated-dose clinical trial.

Setting:

Human-performance and sports-medicine laboratory.

Participants:

36 healthy men.

Methods and Measures:

Baseline testing was performed, 72 hours after which subjects performed eccentric exercise to induce muscle damage. They were evaluated for pain 24 hours postdamage and placed randomly into 3 groups: Vicoprofen (VIC), ibuprofen, or placebo (P). Postdamage testing was performed every day for 5 days. Subjects performed an economy run and a t-agility test to determine exercise performance.

Results:

The drugs had no significant effect on performance throughout the 5-day evaluation period. Pain was lower at days 4 and 5 in the VIC group than in P.

Conclusions:

It appears that Vicoprofen reduced pain after muscle damage, but the drug interventions did not enhance performance in aerobic and agility tasks.

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William J. Kraemer, Ana L. Gómez, Nicholas A. Ratamess, Jay R. Hoffman, Jeff S. Volek, Martyn R. Rubin, Timothy P. Scheett, Michael R. McGuigan, Duncan French, Jaci L. VanHeest, Robbin B. Wickham, Brandon Doan, Scott A. Mazzetti, Robert U. Newton, and Carl M. Maresh

Objective:

To determine the effects of Vicoprofen®, ibuprofen, and placebo on anaerobic performance and pain relief after resistance-exercise-induced muscle damage.

De-sign:

Randomized, controlled clinical study.

Setting:

University human-performance/sports-medicine laboratory.

Participants:

36 healthy men.

Methods and Measures:

After baseline testing (72 h), participants performed an eccentric-exercise protocol. Each was evaluated for pain 24 h later and randomly assigned to a Vicoprofen (VIC), ibuprofen (IBU), or placebo (P) group. Postexercise testing was performed every 24 h for 4 d.

Results:

Significantly greater muscle force, power, and total work were observed in VIC than in P (P < .05) for most time points and for IBU at 48 h.

Conclusions:

Anaerobic performance is enhanced with VIC, especially within the first 24 h after significant muscle-tissue damage. The greater performances observed at 48 h might be a result of less damage at this time point with VIC treatment.