Purpose: To determine the recovery kinetics of performance, muscle damage, and neuromuscular fatigue following 2 speed-endurance production training (SEPT) protocols in soccer. Methods: Ten well-trained, male soccer athletes randomly completed 3 trials: work-to-rest ratio (SEPT) 1:5, SEPT/1:8, and a control trial. Training load during SEPT was monitored using global positioning system and heart-rate monitors. Performance (isokinetic strength of knee extensors and flexors, speed, and countermovement jump) and muscle damage (delayed-onset muscle soreness [DOMS] and creatine kinase) were evaluated at baseline and at 0, 24, 48 and 72 h posttraining. Maximal voluntary contraction (fatigue index) of knee extensors and flexors was additionally assessed at 1, 2, and 3 h posttraining. Results: Fatigue increased (P < .05) in SEPT/1:5 (∼4–30%) for 3 h and in SEPT/1:8 (∼8–17%) for 2 h. Strength performance declined (P < .05) in both SEPT trials (∼5–20%) for 48 h. Speed decreased (∼4–18%; P < .05) for 72 h in SEPT/1:5 and for 48 h in SEPT/1:8. Countermovement-jump performance decreased (∼7–12%; P < .05) in both SEPT trials for 24 h. DOMS increased (P < .05) in SEPT/1:5 (∼2-fold) for 72 and in SEPT/1:8 (∼1- to 2-fold) for 48 h. Creatine kinase increased (∼1- to 2-fold, P < .05) in both SEPT trials for 72 h. Conclusions: SEPT induces short-term neuromuscular fatigue; provokes a prolonged deterioration of strength (48 h), speed (72 h), and jump performance (24 h); and is associated with a prolonged (72-h) rise of DOMS and creatine kinase. Time for recovery is reduced when longer work-to-rest ratios are applied. Fitness status may affect quality of SEPT and recovery kinetics.