The purpose of this study was to explore religiosity/spirituality (R/S) in coping with sport injuries, based on predictions of the integrated model of psychological response to the sport injury and rehabilitation process. A concurrent mixed methods design framed an online survey incorporating quantitative measures of R/S identification and commitment, health locus of control for sport injury, and ways of coping with sport injury, as well as qualitative open-ended questions about mechanisms through which R/S affected and was affected by coping with sport injuries. Participants included 49 physically active adults who experienced sport injuries, with 37 identifying as R/S. Quantitative findings among R/S participants showed religious commitment was a predictor of God health locus of control and positive religious coping. Quantitative results relative to differences between R/S and no-R/S participants showed that those self-identified as R/S relied on a God health locus of control and utilized active coping more so than did those self-identified as no-R/S, whereas no-R/S participants relied more than did R/S participants on an internal health locus of control. Thematic analyses exploring qualitative data revealed three main themes characterizing mechanisms through which R/S affected and was affected by coping with sport injuries: positive, negative, and no R/S coping strategies and effects. Findings support the predictions of the integrated model of psychological response to the sport injury and rehabilitation process and provide evidence-bases for clinical and counseling interventions that reflect cultural competence in accommodating patient or client R/S during recovery from sport injury.