This study attempted to determine the effects of 12-week low- and high-intensity aerobic exercise programs on functional capacity and cardiovascular efficiency of elderly post-coronary artery bypass graft (CABG) patients. Time (Timemax). estimated maximum VO2 (VO2max), heart rate (HRmax), systolic blood pressure(SBPmax), estimated mean arterial blood pressure (MABPmax), and rate × pressure product (RPPmax) were assessed during graded exercise tests before and after 12 weeks of low-intensity (65% HRmax) and high-intensity (85% HRmax) exercise. Subjects (n = 92) were placed in either a low-intensity (LIEX), high-intensity (HIEX), or nonexercising control group (CON). LIEX and HIEX showed increases from pre- to postprogram for Timemax and VO2max. LIEX and HIEX showed decreases for SBPmax, MABPmax, and RPPmax. HIEX and LIEX produced greater improvements than CON for these four variables, while HIEX was superior to LIEX. It was concluded that 12 weeks of low- and high-intensity aerobic exercise can increase functional capacity and cardiovascular efficiency in elderly post-CABG patients; however, high-intensity exercise may produce greater improvements than low-intensity exercise.
Darryn S. Willoughby, Mark Roozen and Randall Barnes
Darryn S. Willoughby and Stephen C. Pelsue
This study was an attempt to determine the effects of 12 weeks of moderate-intensity (MIEX) and high-intensity (HIEX) weight training on the muscular strength and qualitative myosin heavy chain (MHO isoform mRNA expression in 18 elderly men. Subjects were randomly assigned to either a control group (Con) or training groups of either MIEX or HIEX. Training sessions occurred 3 days/week and involved three sets of 15-20 repetitions at 60%-65% 1 -RM for MIEX and three sets of 8-10 repetitions at 75%-80% 1 -RM for HIEX. Both upper and lower body strength increased for Con and increased significantly for MIEX and HIEX. No changes in MHC mRNA isoform expression were observed for Con: however, there were increases in Type I MHC and decreases in Type IIx MHC mRNA expression for MIEX and increases in Type I, Ila, and IIx MHC mRNA expression for HIEX. The findings suggest that both moderate- and high-intensity weight training increases muscle strength and the expression of Type I MHC mRNA isoform. while high-intensity weight training also increases the mRNA expression of Type Ila and IIx isoforms in previously inactive elderly men.
Darryn S. Willoughby, Kaitlan N. Beretich, Marcus Chen and LesLee K. Funderburk
Elevated circulating C-terminal agrin fragment (CAF) is a marker of neuromuscular junction degradation and sarcopenia. This study sought to determine if resistance training (RT) impacted the serum levels of CAF in perimenopausal (PERI-M) and postmenopausal (POST-M) women. A total of 35 women, either PERI-M or POST-M, participated in 10 weeks of RT. Body composition, muscle strength, and serum estradiol and CAF were determined before and after the RT. The data were analyzed with two-way analysis of variance (p ≤ .05). Upper body and lower body strength was significantly increased, by 81% and 73% and 86% and 79% for the PERI-M and POST-M participants, respectively; however, there were no significant changes in body composition. Estradiol was significantly less for the POST-M participants at pretraining compared with the PERI-M participants. CAF moderately increased by 22% for the PERI-M participants in response to RT, whereas it significantly decreased by 49% for the POST-M participants. Ten weeks of RT reduced the circulating CAF in the POST-M women and might play a role in attenuating degenerative neuromuscular junction changes.