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Laura A. Brocklebank, Rob C. Andrews, Angie Page, Catherine L. Falconer, Sam Leary and Ashley Cooper

Background:

The aim of this randomized, 3-period, 3-treatment crossover trial was to examine the acute effects of regularly breaking up seated office work with short bouts of standing or light-intensity walking on postprandial interstitial glucose concentration.

Methods:

Seventeen middle-aged office workers performed 3 5-hour trial conditions at their workplace in a random order: 1) uninterrupted sitting, 2) sitting interrupted by 2 minutes of standing every 20 minutes, and 3) sitting interrupted by 2 minutes of light-intensity walking every 20 minutes. Participants consumed 2 standardized test drinks at the start of each trial condition and an iPro2 continuous glucose monitoring system (CGMS) recorded average interstitial glucose concentration every 5 minutes for the duration of the study.

Results:

The 5-hour interstitial glucose incremental area under the curve (iAUC) was 55.5% lower after sitting interrupted by light-intensity walking compared with after uninterrupted sitting (95% CI, –104.2% to –6.8%). There was also a suggestion of a beneficial effect of regular standing breaks, particularly in overweight men, although they were not as effective as the walking breaks (mean difference [95% CI], –29.6% [–73.9% to 14.7%]).

Conclusions:

Regularly breaking up prolonged sitting lowers postprandial glycemia in middle-aged adults without metabolic impairment.

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Chris Riddoch, Dawn Edwards, Angie Page, Karsten Froberg, Sigmund A. Anderssen, Niels Wedderkopp, Søren Brage, Ashley R. Cooper, Luis B. Sardinha, Maarike Harro, Lena Klasson-Heggebø, Willem van Mechelen, Colin Boreham, Ulf Ekelund, Lars Bo Andersen and The European Youth Heart Study Team

Background:

The aim of the European Youth Heart Study (EYHS) is to establish the nature, strength, and interactions between personal, environmental, and lifestyle influences on cardiovascular disease (CVD) risk factors in European children.

Methods:

The EYHS is an international study measuring CVD risk factors, and their associated influences, in children. Relationships between these independent factors and risk of disease will inform the design of CVD interventions in children. A minimum of 1000 boys and girls ages 9 and 15 y were recruited from four European countries—Denmark, Estonia, Norway, and Portugal. Variables measured included physical, biochemical, lifestyle, psychosocial, and sociodemographic data.

Results:

Of the 5664 children invited to participate, 4169 (74%) accepted. Response rates for most individual tests were moderate to high. All test protocols were well received by the children.

Conclusions:

EYHS protocols are valid, reliable, acceptable to children, and feasible for use in large, field-based studies.