The purpose of this investigation was to (1) quantify the training load practices of a professional soccer goalkeeper and (2) investigate the relationship between the training load observed and the subsequent self-reported wellness response. One male goalkeeper playing for a team in the top league of the Netherlands participated in this case study. Training load data were collected across a full season using a global positioning system device and session-RPE (rating of perceived exertion). Data were assessed in relation to the number of days to a match (MD− and MD+). In addition, self-reported wellness response was assessed using a questionnaire. Duration, total distance, average speed, PlayerLoad™, and load (derived from session-RPE) were highest on MD. The lowest values for duration, total distance, and PlayerLoad™ were observed on MD−1 and MD+1. Total wellness scores were highest on MD and MD−3 and were lowest on MD+1 and MD−4. Small to moderate correlations between training load measures (duration, total distance covered, high deceleration efforts, and load) and the self-reported wellness response scores were found. This exploratory case study provides novel data about the physical load undertaken by a goalkeeper during 1 competitive season. The data suggest that there are small to moderate relationships between training load indicators and self-reported wellness response. This weak relation indicates that the association is not meaningful. This may be due to the lack of position-specific training load parameters that practitioners can currently measure in the applied context.