The purpose was to determine predictors of the gross motor development quotient of the Test of Gross Motor Development (Ulrich, 1985) for young children prenatally exposed to cocaine/polydrugs. Data were collected on 11 variables hypothesized to influence young children’s development. Participants were 28 children (15 males, 13 females), ages 3 to 6 years, exposed prenatally to cocaine/polydrugs and their nonbiological mothers (i.e., primary care providers). Multiple regression procedures indicated support for the hypothesis that the gross motor development quotient is predicted by the interaction of the child’s effortful control, the primary care provider’s understanding and confidence, and the amount of early intervention service the child received. Correlational analysis supported the hypothesis that with this group of children, early motor skill did not predict delay in the gross motor development quotient at ages 3 to 6 years.