Background: Men with prostate cancer (PCa) may be referred to cardiac rehabilitation (CR) following a significant cardiac event, but it is unknown if these men have different effects of CR from men without a history of PCa. Purpose: To compare the effect of CR on cardiorespiratory fitness (VO2peak), body fat percentage, and body mass index in men with and without a history of PCa. Methods: CR participants with PCa were retrospectively compared with a cohort matched on age, clinical indication for CR, and date of referral to the CR program. Participants completed the standardized CR program at the Toronto Rehabilitation Institute, including 1 weekly supervised group session and 4 additional weekly home sessions including aerobic and resistance training for 26 weeks. Results: Twenty-seven (n = 27) men with PCa were identified and matched 1∶1 with controls. VO2peak increased in the PCa group (16.9 [5.1]–19.6 [6.2] mL·kg−1·min−1; Δ 2.7 mL·kg−1·min−1, P < .05) and in the control group (16.4 [4.2]–20.2 [5.8] mL·kg−1·min−1; Δ 3.8 mL·kg−1·min−1, P < .05) as a result of engaging in CR. There were no significant between-group differences in the postintervention outcomes (P > .05). Conclusions: Men with and without PCa experience comparable benefits following CR completion.
Alis Bonsignore, David Field, Rebecca Speare, Lianne Dolan, Paul Oh and Daniel Santa Mina
Daniel Santa Mina, Shabbir M.H. Alibhai, Andrew G. Matthew, Crissa L. Guglietti, Meysam Pirbaglou, John Trachtenberg and Paul Ritvo
Androgen-deprivation therapy (ADT) for prostate cancer (PCa) has side effects that significantly impair health-related quality of life (HRQOL). Exercise ameliorates many side effects of ADT, but different modalities, particularly in the home-based setting, have not been well studied. In this study the authors randomly assigned 66 PCa survivors receiving ADT to 6 mo of home-based aerobic or resistance training. Psychosocial well-being and physical fitness were measured at baseline, 3 and 6 mo, and then 6 mo postintervention. Intention-to-treat analyses showed that fatigue and HRQOL were not significantly different between groups; however, in a per-protocol analysis the resistance-exercise training group demonstrated clinically significant improvements in HRQOL. Differential within-group effects on physical fitness were also observed at various time points. At all time points, the aerobic-training group engaged in significantly more physical activity than the resistance-training group, a finding that should be further examined given evidence-based guidelines for activity volume in cancer survivors.