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Alis Bonsignore, David Field, Rebecca Speare, Lianne Dolan, Paul Oh and Daniel Santa Mina

Background: Men with prostate cancer (PCa) may be referred to cardiac rehabilitation (CR) following a significant cardiac event, but it is unknown if these men have different effects of CR from men without a history of PCa. Purpose: To compare the effect of CR on cardiorespiratory fitness (VO2peak), body fat percentage, and body mass index in men with and without a history of PCa. Methods: CR participants with PCa were retrospectively compared with a cohort matched on age, clinical indication for CR, and date of referral to the CR program. Participants completed the standardized CR program at the Toronto Rehabilitation Institute, including 1 weekly supervised group session and 4 additional weekly home sessions including aerobic and resistance training for 26 weeks. Results: Twenty-seven (n = 27) men with PCa were identified and matched 1∶1 with controls. VO2peak increased in the PCa group (16.9 [5.1]–19.6 [6.2] mL·kg−1·min−1; Δ 2.7 mL·kg−1·min−1, P < .05) and in the control group (16.4 [4.2]–20.2 [5.8] mL·kg−1·min−1; Δ 3.8 mL·kg−1·min−1, P < .05) as a result of engaging in CR. There were no significant between-group differences in the postintervention outcomes (P > .05). Conclusions: Men with and without PCa experience comparable benefits following CR completion.

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Daniel Santa Mina, Shabbir M.H. Alibhai, Andrew G. Matthew, Crissa L. Guglietti, Meysam Pirbaglou, John Trachtenberg and Paul Ritvo

Androgen-deprivation therapy (ADT) for prostate cancer (PCa) has side effects that significantly impair health-related quality of life (HRQOL). Exercise ameliorates many side effects of ADT, but different modalities, particularly in the home-based setting, have not been well studied. In this study the authors randomly assigned 66 PCa survivors receiving ADT to 6 mo of home-based aerobic or resistance training. Psychosocial well-being and physical fitness were measured at baseline, 3 and 6 mo, and then 6 mo postintervention. Intention-to-treat analyses showed that fatigue and HRQOL were not significantly different between groups; however, in a per-protocol analysis the resistance-exercise training group demonstrated clinically significant improvements in HRQOL. Differential within-group effects on physical fitness were also observed at various time points. At all time points, the aerobic-training group engaged in significantly more physical activity than the resistance-training group, a finding that should be further examined given evidence-based guidelines for activity volume in cancer survivors.