The present study examined the relationships among the AAHPERD Physical Best health related physical fitness test (HRPFT) items to resting blood pressure in 80 boys and 84 girls from the Lanciano, Italy, school system. Systolic blood pressure (SBP) was significantly associated with age for both sexes. Diastolic blood pressure (DBP) for boys was found to be associated with fatness when age was held constant. To examine the relationship between blood pressure and the HRPFT, data were sorted into two groups of students passing or failing to meet the criterion-referenced standard (CRS) by 1-mile run performance and sum of skinfolds. SBP did not differ significantly between groups for either sex. Boys who failed to meet the CRS for 1-mile run performance showed a higher DBP of 4 mmHg when compared to boys who achieved the CRS. The group passing the aerobic fitness and body composition tests tended to perform better on all test items. With the possible exception of DBP for boys, it is concluded that performance on the Physical Best HRPFT is not associated with resting blood pressure in children and adolescents.