The purpose of this study was to investigate the prevalence of depressive and anxiety symptoms within student-athletes and to examine protective factors which may act as a buffer against mental ill-health. A cross-sectional design was employed. A sample of 185 student-athletes (M = 20.77; SD = .50; 35% female) agreed to take part. Participants completed measures of depression, anxiety, psychological resilience and formal and informal help-seeking behavior. Thirty one percent of student-athletes reported moderate to severe symptoms of depression and/or anxiety. Student-athletes who reported requiring professional help for problems were more likely to record moderate to severe symptoms of depression and anxiety. Student-athletes who did not seek informal support were more likely to report symptom levels for depression outside the normal range. Higher resilience scores were associated with lower symptom reporting for both depression and anxiety. Practical implications for supporting student-athletes’ mental health across institutional, interpersonal and intrapersonal levels are discussed.