Behavioral, response outcome, and response kinematic measures were analyzed for 6 adults (5 males and 1 female) with profound mental retardation (PMR). Participants performed 30 error-free simple linear aiming movements on a digitizing tablet during 7 acquisition, 3 retention, and 4 transfer days. A one-way ANOVA on the number of trials to reach 30 error-free responses revealed that adults with PMR improved, learned the skill, and transferred it to a new situation. The 2 × 3 × 3 (Phase × Day × Block) repeated measures ANOVAs for response outcome and kinematic measures indicated that participants were able to initiate movement faster with practice. However, practice did not result in changes in kinematic response measures.