Adolescent girls are becoming less physically active and are experiencing more body image issues compared to adolescent boys. Furthermore, adolescent girls maintain physical activity levels well below recommended guidelines, especially girls in urban environments. The purpose of this study was to examine the effect of an 8-week after-school educational curriculum, GoGirlGo!, and physical activity program on urban adolescent middle school girls’ attitudes toward physical activity and body image. Twenty-five girls ranging in age from 12 to 14 years of age (M = 12.34 years, SD = 2.1) were randomly placed into two groups: (a) GoGirlGo! intervention and physical activity, and (b) physical activity only. The GoGirlGo! group increased their attraction to physical activity and lowered scores in weight dissatisfaction and desire to be slim compared to the physical activity only group. Based on the data, the GoGirlGo! curriculum is effective in improving attitudes about physical activity and body image among urban adolescent girls.