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  • Author: Lisa Cadmus-Bertram x
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Christopher Kuenze, Lisa Cadmus-Bertram, Karin Pfieffer, Stephanie Trigsted, Dane Cook, Caroline Lisee and David Bell

Context: Reductions in objectively measured moderate to vigorous physical activity (MVPA) have been reported among individuals with anterior cruciate ligament reconstruction (ACLR). Self-reported measures of physical activity are commonly used to assess participation in physical activity after ACLR despite the lack of evidence to support the validity of such measures within this population. Objective: The objective of this research was to determine the relationships between objectively measured MVPA, self-reported physical activity, and knee function among individuals with ACLR. Setting: University laboratory. Patients (or Other Participants): Thirty-one participants with a history of ACLR (sex: 23 females and 8 males; age = 19.8 [1.4] y) and 31 matched controls (sex: 23 females and 8 males; age = 20.6 [1.7] y) enrolled in this study. Intervention(s): None. Main Outcome Measures: Participants completed self-reported physical activity using the Tegner Activity Scale and the Marx Activity Rating Scale. Participant MVPA was objectively measured using an ActiGraph wGT3X-BT accelerometer for a 7-day period during which the monitor was worn for not less than 10 hours per day. Primary outcome measures were the amount of time spent in MVPA (minutes per week) and time spent in MVPA performed in bouts of ≥10 minutes (minutes per week). Relationships between the Tegner Activity Score, Marx Activity Rating Scale, and objectively measured MVPA variables were assessed using partial Spearman’s rank correlation coefficients after controlling for activity monitor wear time. Results: There were no significant relationships between objectively measured MVPA and self-reported physical activity (ρ ≤ 0.31, P ≥ .05) or self-reported knee-related function (ρ ≤ .41, P ≥ .05) among ACLR participants. Conclusions: Objectively measured physical activity is not significantly related to self-reported physical activity or self-reported knee function among individuals with a history of ACLR. Consideration of objective and self-reported physical activity within this population may provide key insights into disconnects between perception and the reality of physical activity engagement following ACLR.

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Lisa A. Cadmus Bertram, Gina Chung, Herbert Yu, Peter Salovey and Melinda Irwin

Background:

The purpose of this study was to determine the feasibility of using a tumor registry to recruit newly diagnosed survivors into a randomized controlled exercise trial and to discuss issues related to this recruitment strategy.

Methods:

A tumor registry-based rapid ascertainment system was used to recruit breast cancer survivors into a 6-month home-based, telephone-administered intervention of moderate-to-vigorous intensity exercise or a usual care group.

Results:

468 newly diagnosed cases were identified. Of these, 50 women (15.4% of those for which screening calls were made) were enrolled in the study. Women were randomized, on average, 11 weeks after diagnosis (SD = 4.8). Sixty-four percent were randomized before beginning treatment or within the first week of treatment. Time required to obtain physician consent was the primary determinant of diagnosis-to-randomization latency. Enrolled women were more likely than nonenrolled women to be non-Hispanic White and to have a college degree (P < .05).

Conclusion:

Tumor registries present a feasible means of recruiting breast cancer survivors before or early in adjuvant treatment. The success of recruiting survivors promptly after diagnosis is largely dependent on ability to rapidly obtain physician consent. Specific effort is needed to counteract self-selection effects that may lead to under-representation of minorities.

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Kristin Campbell, Karen Foster-Schubert, Liren Xiao, Catherine Alfano, Lisa Cadmus Bertram, Catherine Duggan, Melinda Irwin and Anne McTiernan

Background:

The risk of musculoskeletal injury with the introduction of moderate-to-vigorous exercise in sedentary adults is not well established. The purpose of this report is to examine the effect of a 12-month exercise intervention on musculoskeletal injury and bodily pain in predominately overweight, sedentary men (n = 102) and women (n = 100), ages 40 to 75 years.

Methods:

Participants were randomized to a moderate-to-vigorous aerobic exercise intervention (EX) (6 d/wk, 60 min/d, 60% to 85% max. heart rate) or usual lifestyle control (CON). Participants completed a self-report of musculoskeletal injury and body pain at baseline and 12-months.

Results:

The number of individuals reporting an injury (CON; 28% vs. EX; 28%, P = .95) did not differ by group. The most commonly injured site was lower leg/ankle/foot. The most common causes of injury were sports/physical activity, home maintenance, or “other.” In the control group, bodily pain increased over the 12 months compared with the exercise group (CON −7.9, EX −1.4, P = .05). Baseline demographics and volume of exercise were not associated with injury risk.

Conclusions:

Previously sedentary men and women randomized to a 12-month aerobic exercise intervention with a goal of 360 min/wk reported the same number of injuries as those in the control group and less bodily pain.

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Simon Marshall, Jacqueline Kerr, Jordan Carlson, Lisa Cadmus-Bertram, Ruth Patterson, Kari Wasilenko, Katie Crist, Dori Rosenberg and Loki Natarajan

The purpose of this study was to compare estimates of sedentary time on weekdays vs. weekend days in older adults and determine if these patterns vary by measurement method. Older adults (N = 230, M = 83.5, SD = 6.5 years) living in retirement communities completed a questionnaire about sedentary behavior and wore an ActiGraph accelerometer for seven days. Participants engaged in 9.4 (SD = 1.5) hr per day of accelerometer-measured sedentary time, but self-reported engaging in 11.4 (SD = 4.9) hr per day. Men and older participants had more accelerometer-measured sedentary time than their counterparts. The difference between accelerometer-measured weekday and weekend sedentary time was nonsignificant. However, participants self-reported 1.1 hr per day more sedentary time on weekdays compared with weekend days. Findings suggest self-reported but not accelerometer-measured sedentary time should be investigated separately for weekdays and weekend days, and that self-reports may overestimate sedentary time in older adults.

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Lisa Cadmus-Bertram, Melinda Irwin, Catherine Alfano, Kristin Campbell, Catherine Duggan, Karen Foster-Schubert, Ching-Yun Wang and Anne McTiernan

Background:

The purpose of this study was to (a) examine demographic, psychosocial, and physiological predictors of exercise adherence in a yearlong exercise intervention and (b) describe the trajectory of adherence over time.

Methods:

Participants were 51 men and 49 women aged 40 to 75 years. The supervised and home-based intervention consisted of 60 minutes/day, 6 days/week of moderate-to-vigorous intensity exercise. Three adherence measures were used: (1) minutes/week, (2) MET-hours/week, and (3) change in cardiopulmonary fitness (VO2max). Predictors of adherence were determined separately by sex using mixed models and multivariable regression.

Results:

Participants performed 287 ± 98 minutes/week of moderate-to-vigorous activity with 71% adhering to at least 80% (288 minutes/week) of the prescription. Men adhered better than women (P < .001). Among women, adiposity-related variables were significantly related to poorer adherence on all 3 measures (P < .05). A less consistent pattern was observed among men but in follow-up analyses, adiposity was associated with fewer MET-hours/week of exercise. Social support, pain, and perceived benefits were predictive in some models. Men and nonobese women experienced peak adherence at 4 to 6 months, while obese women peaked during months 0 to 3.

Conclusions:

When provided with supervision and support, previously sedentary men and women can achieve and maintain high levels of aerobic activity.

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Sheri J. Hartman, Catherine R. Marinac, Lisa Cadmus-Bertram, Jacqueline Kerr, Loki Natarajan, Suneeta Godbole, Ruth E. Patterson, Brittany Morey and Dorothy D. Sears

Background: Sedentary behavior is associated with increased risk of poor outcomes in breast cancer survivors, but underlying mechanisms are not well understood. This pilot study explored associations between different aspects of sedentary behaviors (sitting, prolonged sitting, sit-to-stand transitions, and standing) and breast cancer risk-related biomarkers in breast cancer survivors (n = 30). Methods: Sedentary behavior variables were objectively measured with thigh-worn activPALs. Breast cancer risk-related biomarkers assessed were C-reactive protein (CRP), insulin, and homeostatic model assessment of insulin resistance (HOMA-IR) and were measured in fasting plasma samples. Linear regression models were used to investigate associations between sedentary behavior variables and biomarkers (log CRP, insulin, and HOMA-IR). Results: Sit-to-stand transitions were significantly associated with insulin resistance biomarkers (P < .05). Specifically, each 10 additional sit-to-stand transitions per day was associated with a lower fasting insulin concentration (β = −5.52; 95% CI, −9.79 to −1.24) and a lower HOMA-IR value (β = −0.22; 95% CI, −0.42 to −0.03). Sit-to-stand transitions were not significantly associated with CRP concentration (P = .08). Total sitting time, long sitting bouts, and standing time were not significantly associated with CRP, insulin, or HOMA-IR (P > .05). Conclusions: Sit-to-stand transitions may be an intervention target for reducing insulin resistance in breast cancer survivors, which may have favorable downstream effects on cancer prognosis.