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Catherine B. Woods, Norah M. Nelson, Donal J. O’Gorman, Eimear Foley and Niall M. Moyna


The Take PART study—Physical Activity Research for Teenagers—was undertaken to assess (1) physical activity and sedentary behaviors, (2) indices of health and fitness, and (3) to provide information, from a social ecological perspective, on the correlates of physical activity in a large sample of 15- to 17-year-old Irish adolescents. This manuscript outlines the rationale and methodology of the Take PART study.


A sample of 4720 students (mean age = 16.03 years ± 0.66, range 15 to 17 years; 49.5% female) participated. Fifty participants were assessed during each 3-hour school visit, with a ratio of 1 researcher to 10 students. Standardized testing procedures and extensive researcher training ensured that intertester and intratester reliability for all physical measures was ≥.85. The height, weight, waist circumference, hip circumference, blood pressure, and cardiorespiratory fitness protocols are explained. The questionnaire used well-known, valid, and reliable self-report measures. Where appropriate, additional psychometric testing was undertaken.


Take PART is a school-based study. Its methods are simple, easy to replicate, financially viable, and scientifically valid. Its unique dataset will allow the evaluation of a social ecological approach as a viable option for improving understanding of youth inactivity. Ultimately, this knowledge will assist in successful intervention design.

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Judith M. Lukaszuk, Robert J. Robertson, Judith E. Arch, Geoffrey E. Moore, Kenneth M. Yaw, David E. Kelley, Joshua T. Rubin and Niall M. Moyna

The purpose of this investigation was to examine the effects of preceding oral creatine monohydrate with a lacto-ovo-vegetarian diet on muscle creatine concentration. Thirty-two healthy men, who regularly consumed an omnivorous diet, were randomly assigned to consume a weight maintaining, lacto-ovo-vegetarian (LOV; n = 16) or omnivorous (Omni; n = 16) diet for 26 days. In addition to their assigned diet, on day 22 of the study, subjects were assigned in a double-blind manner to receive either creatine monohydrate (CM; 0.3 g · kg · d−1 + 20 g Polycose) or an equivalent dose of placebo (PL) for 5 days. There were no significant differences between the LOV and Omni groups at baseline with respect to age, height, and weight. The results demonstrated that consuming a LOV diet for 21 days was an effective procedure to decrease muscle creatine concentration (p < .01) in individuals who normally consume meat and fish in their diet. However, muscle total creatine (TCr) following creatine supplementation did not differ statistically between LOV and Omni diet groups (148.6 ± 4.5 vs. 141.7 ± 4.5 mmol · kg−1 d.m.).

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Kieran Dowd, Deidre Harrington, Ailish Hannigan, Helen Purtill, Sarah M. Kelly, Alan P. Macken, Niall Moyna, Clodagh S. O’Gorman and Alan E. Donnelly


This study aims to (1) use the objective activPAL activity monitor to assess physical activity behaviors, including sitting/lying, standing, and both light (LIPA) and moderate-to-vigorous physical activity (MVPA); (2) to develop distinct activity profiles based on time spent in each behavior in a sample of adolescent females; and (3) examine whether levels of adiposity differ across these activity profiles.


Female adolescents (n = 195; 14–18 y) had body mass index (median = 21.7 [IQR = 5.2] kg/m2) and 4-site skinfold thickness (median 62.0 mm; IQR = 37.1) measured. Physical activity behaviors were measured using the activPAL. Hierarchical cluster analysis grouped participants into activity profiles based on similar physical activity characteristics. Linear mixed models explored differences in body composition across activity profiles.


Three activity profiles were identified, a low (n = 35), moderate (n = 110), and a high activity profile (n = 50). Significant differences across activity profiles were observed for skinfold thickness (p = .046), with higher values observed in the low activity profile compared with the high activity profile.


Profiling free-living activity using behaviors from across the activity intensity continuum may account for more of the variability in energy expenditure then examining specific activity intensities, such as MVPA alone. The use of activity profiles may enable the identification of individuals with unhealthy activity behaviors, leading to the development and implementation of more targeted interventions.

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Joshua Lowndes, Robert F. Zoeller, George A. Kyriazis, Mary P. Miles, Richard L. Seip, Niall M. Moyna, Paul S. Visich, Linda S. Pescatello, Paul M. Gordon, Paul D. Thompson and Theodore J. Angelopoulos

The purpose of this study was to examine whether leptin levels affect the response of leptin to exercise training (ET) and whether this is also affected by C-reactive protein (CRP) or the three common Apolipoprotein E genotypes (APOE). Ninety-seven (male = 45, female = 52) sedentary individuals underwent 6 months of supervised ET. Blood was sampled before the initiation of ET, and again 24 and 72 hr after completion of the final training session. ET resulted in a small reduction in body mass (80.47 ± 18.03 vs 79.42 ± 17.34 kg, p < .01). Leptin was reduced 24 hr after the final exercise session (p < .01), but returned to normal after 72 hr (p > .05)—Pre: 13.51 ± 12.27, 24hr: 12.14 ± 12.34, 72hr: 12.98 ± 11.40 ng/ml. The most hyperleptinemic individuals had a greater initial response, which was sustained through to 72 hr after the final session in the pooled study population (p < .01), and in both males (p < .05) and females (p < .05) separately. CRP was related to leptin independently of body weight and positively related to the reductions in leptin. APOE genotype was not related to leptin levels and did not affect the response to ET. Leptin levels may only be reduced by ET in those with hyperleptinemia. In addition, both the initial extent of hyperleptinemia and the subsequent reduction in leptin may be related to low grade chronic systemic inflammation.