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Gregory M. Gutierrez, Nicole D. Jackson, Kristin A. Dorr, Sarah E. Margiotta and Thomas W. Kaminski


Lateral ankle sprains occur more frequently than any other orthopedic injury. Athletes often report sustaining more injuries late in competition when fatigue is present.


To evaluate neuromuscular function of the ankle musculature after fatigue. Design: Experimental, pretest-posttest.


Research laboratory.


Ten female and 9 male college-aged subjects.


Fatigue was induced via continuous concentric and eccentric muscle actions of the ankle: inversion (INV), eversion (EV), plantar flexion (PF), and dorsiflexion (DF).

Main Outcome Measures:

Peak torque (PT), peak EMG, and median frequency (MF) were calculated prefatigue and postfatigue in the tibialis anterior (TA), peroneus longus (PER), and lateral gastrocnemius (GAS) muscles.


Main effects were noted for test (P < 0.0125) in all statistical tests performed indicating changes in PT, peak EMG, and MF after fatigue.


A significant decrease in MF of the PER muscle after PF fatigue and corresponding with a decreased firing rate, may be of importance, especially with regard to the role in countering the violent moment seen with inversion ankle sprains.

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Lee Smith, Brendon Stubbs, L. Hu, Nicola Veronese, Davy Vancampfort, Genevieve Williams, Domenico Vicinanza, Sarah E. Jackson, Li Ying, Guillermo F. López-Sánchez and Lin Yang

Background: To investigate the association between levels of active transport and leisure-time physical activity (LTPA) with C-reactive protein, white blood cell count, body mass index, waist circumference, and lipids in a large representative sample of adults residing in the United States. Methods: Cross-sectional data from the National Health and Nutrition Examination Survey. Adjusted multinomial logistic regressions were carried out to quantify associations between levels of self-reported active transport (or LTPA) and quintiles of anthropometric measures and serum markers. Results: A total of 3248 adults were included. For serum inflammatory biomarkers, the authors observed a lower likelihood of being in the top quintile groups of circulating C-reactive protein (adjusted odds ratio [aOR]: 0.60; 95% confidence interval [CI], 0.40–0.90) and white blood cell count (aOR: 0.65; 95% CI, 0.44–0.95) with engaging in low to medium levels of active transport but not with high levels of active transport. Higher levels of LTPA were associated with lower likelihood of having high levels of serum inflammatory biomarkers (aOR: 0.60; 95% CI, 0.42–0.86 in the top C-reactive protein group and aOR: 0.58; 95% CI, 0.39–0.87 in top white blood cell group). Conclusions: Promoting active transport and/or LTPA may be a beneficial strategy to improving some, but not all, cardiometabolic health outcomes.