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Thomas Rowland


Patients with repaired tetralogy of Fallot have good long-term survival but less is known about the subjectively assessed quality of life or objectively measured functional status of those who have not required subsequent pulmonary valve replacement. We assessed these parameters in a group of children and adults free from pulmonary valve replacement after tetralogy of Fallot repair.

Methods and Results:

A random sample of 50 subjects—16 children and 34 adults, aged 4.1-56.7 years—who had undergone tetralogy of Fallot repair and were free from subsequent pulmonary valve replacement underwent cardiopulmonary exercise testing and completed standardized questionnaires assessing health related quality of life and resilience. Patients were generally asymptomatic (median New York Heart Association class = 1). Exercise capacity was within two standard deviations of normal for most children and adults (mean z VO2max: 0.20 + 1.5; mean z VO2max: 0.20 + 1.5; mean z VE/VCO2 −0.9 + 1.3). Children reported a total health-related quality of life score similar to healthy norms (78 + 10 versus 84 + 1, p = .73). Adult survivors also reported quality of life scores comparable to healthy norms. Resilience was highly correlated with all domains of health-related quality of life (r = .713, p < .0001).


Patients who have undergone tetralogy of Fallot repair in childhood and have not required pulmonary valve replacement have a good long-term health-related quality of life. The finding that patients with greater resilience had better health-related quality of life suggests that it may be beneficial to implement interventions to foster resilience.

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Michael J. LaMonte, I-Min Lee, Eileen Rillamas-Sun, John Bellettiere, Kelly R. Evenson, David M. Buchner, Chongzhi Di, Cora E. Lewis, Dori E. Rosenberg, Marcia L. Stefanick and Andrea Z. LaCroix

Background: Limited data are available regarding the correlation between questionnaire and device-measured physical activity (PA) and sedentary behavior (SB) in older women. Methods: We evaluated these correlations in 5,992 women, aged 63 and older, who completed the Women’s Health Initiative (WHI) and Community Healthy Activities Model Program for Seniors (CHAMPS) PA questionnaires and the CARDIA SB questionnaire prior to wearing a hip-worn accelerometer for 7 consecutive days. Accelerometer-measured total, light, and moderate-to-vigorous PA (MVPA), and total SB time were defined according to cutpoints established in a calibration study. Spearman coefficients were used to evaluate correlations between questionnaire and device measures. Results: Mean time spent in PA and SB was lower for questionnaire than accelerometer measures, with variation in means according to age, race/ethnicity, body mass index, and functional status. Overall, correlations between questionnaires and accelerometer measures were moderate for total PA, MVPA, and SB (r ≈ 0.20–0.40). Light intensity PA correlated weakly for WHI (r ≈ 0.01–0.06) and was variable for CHAMPS (r ≈ 0.07–0.22). Conclusion: Questionnaire and accelerometer estimates of total PA, MVPA, and SB have at best moderate correlations in older women and should not be assumed to be measuring the same behaviors or quantity of behavior. Light intensity PA is poorly measured by questionnaire. Because light intensity activities account for the largest proportion of daily activity time in older adults, and likely contribute to its health benefits, further research should investigate how to improve measurement of light intensity PA by questionnaires.

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Rangasamy Suresh Babu, P. Anand, Mathew Jeraud, P. Periasamy and A. Namasivayam

Experimental studies concerning the analysis of locomotor behavior in spinal cord injury research are widely performed in rodent models. The purpose of this study was to quantitatively evaluate the degree of functional recovery in reflex components and bipedal locomotor behavior of bonnet macaques (Macaca radiata) after spinal contusive injury. Six monkeys were tested for various reflex components (grasping, righting, hopping, extension withdrawal) and were trained preoperatively to walk in bipedal fashion on the simple and complex locomotor runways (narrow beam, grid, inclined plane, treadmill) of this investigation. The overall performance of the animals’ motor behavior and the functional status of limb movements during bipedal locomotion were graded by the Combined Behavioral Score (CBS) system. Using the simple Allen weight-drop technique, a contusive injury was produced by dropping a 13-g weight from a height of 30 cm to the exposed spinal cord at the T12-L1 vertebral level of the trained monkeys. All the monkeys showed significant impairments in every reflex activity and in walking behavior during the early part of the postoperative period. In subsequent periods, the animals displayed mild alterations in certain reflex responses, such as grasping, extension withdrawal, and placing reflexes, which persisted through a 1-year follow-up. The contused animals traversed locomotor runways—narrow beam, incline plane, and grid runways—with more steps and few errors, as evaluated with the CBS system. Eventually, the behavioral performance of all spinal-contused monkeys recovered to near-preoperative level by the fifth postoperative month. The findings of this study reveal the recovery time course of various reflex components and bipedal locomotor behavior of spinal-contused macaques on runways for a postoperative period of up to 1 year. Our spinal cord research in primates is advantageous in understanding the characteristics of hind limb functions only, which possibly mimic the human motor behavior. This study may be also useful in detecting the beneficial effect of various donor tissue–neuroprotective drugs on the repair of impaired functions in a bipedal primate model of spinal injury.

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10 1 4 27 10.1123/japa.10.1.4 Exercise Performance, Functional Status, and Hemodynamic Assessment of Elderly Patients with Intermittent Claudication Michael R.M. McGuigan * Roger Bronks * Robert U. Newton * John C. Graham * David V. Cody * 1 2002 10 1 28 40 10.1123/japa.10.1.28 Master

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Original Research Vertical Ground Reaction Forces are Associated with Pain and Self-Reported Functional Status in Recreational Athletes with Patellofemoral Pain Danilo de Oliveira Silva * Ronaldo Briani * Marcella Pazzinatto * Deisi Ferrari * Fernando Aragão * Fábio de Azevedo * 12 2015

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Salih A. Salih, Nancye M. Peel, Di Enright and Wendy Marshall

there were significant improvements in the measured functional status at discharge from TCP, including PA level. Less time was spent being sedentary and the ‘uptime’ was significantly increased by 27.1% on discharge (mean difference 45 minutes SEM 18 minutes). The majority of clients attained or

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Guy C. Wilson, Yorgi Mavros, Lotti Tajouri and Maria Fiatarone Singh

) (frailty) (functional independence) (performance based test) (SPPB) (short physical performance battery) (TUG) (timed up and go) (walking speed) (gait velocity) (ambulation) (tandem walk) (tandem stand) (one legged stand) (forward reach) (lateral sway) (functional status) Note . Search terms: 88 search

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Brett D. Tarca, Thomas P. Wycherley, Paul Bennett, Anthony Meade and Katia E. Ferrar

function and the modifiable factors will also be explored. Findings from this review may assist in the development of evidence-based assessment batteries to monitor and predict future functional status or inform the development of exercise-based interventions to promote improved physical function in this

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Renata V. Pedroso, Carlos Ayán, Francisco J. Fraga, Thays M.V. da Silva, José M. Cancela and Ruth F. Santos-Galduròz

few studies have tested the efficacy of functional-task training on cognitively impaired populations and have found improvements in the cognitive function, ADL performance, and the functional status among institutionalized people with dementia ( Law, Barnett, Yau, & Gray, 2014 ; Littbrand, Lundin

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Giovanni Mario Pes, Maria Pina Dore, Alessandra Errigo and Michel Poulain

this study, daily physical activity and its relationships with functional status were assessed in free-living nonagenarians from the village of Villagrande (Sardinia), a well-known longevity area. The study may contribute to the planning of activity programs able to improve physical performance in