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Adam D. Osmond, Dean J. Directo, Marcus L. Elam, Gabriela Juache, Vince C. Kreipke, Desiree E. Saralegui, Robert Wildman, Michael Wong and Edward Jo

Acute performance deficits during training or competition result, in part, from skeletal-muscle damage provoked by prior high-intensity, overloading exercise. Evidence suggests that exercise-induced muscle damage (EIMD) impedes muscular force production (ie, muscle strength), movement kinematics

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Mads S. Larsen, Dagmar Clausen, Astrid Ank Jørgensen, Ulla R. Mikkelsen and Mette Hansen

( Levenhagen et al., 2001 ; van Loon et al., 2000 ), and markers of immune function ( Witard et al., 2014 ). Furthermore, studies show an accelerated regain of strength and function following a single bout of muscle-damaging resistance exercise when supplementing with whey protein ( Buckley et al., 2010

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Jordan D. Philpott, Chris Donnelly, Ian H. Walshe, Elizabeth E. MacKinley, James Dick, Stuart D.R. Galloway, Kevin D. Tipton and Oliver C. Witard

are implicated in causing skeletal muscle fiber damage ( Nédélec et al., 2012 ; Russell et al., 2015 ). Multiple physiological events underpin the muscle damage process following eccentric-based exercise. Mechanical loading on muscle fibers initially serves to overstretch some myofilaments, resulting

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Ahmed Ismaeel, Michael Holmes, Evlampia Papoutsi, Lynn Panton and Panagiotis Koutakis

ROS ( Steinbacher & Eckl, 2015 ). Notably, consumption of antioxidant supplements has become a very common practice for athletes and physically active individuals in a perceived attempt to enhance training, speed up recovery, and limit muscle damage and soreness ( Gomez-Cabrera et al., 2008

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Aline C. Tritto, Salomão Bueno, Rosa M.P. Rodrigues, Bruno Gualano, Hamilton Roschel and Guilherme G. Artioli

increased LBM by ∼8.5 and ∼7.5 kg, respectively. It has been argued that the free acid form of HMB may explain such positive results because HMB-FA has greater bioavailability than its calcium salt form (HMB-Ca; Fuller et al., 2011 ). Another explanation lies in the ability of HMB to minimize muscle damage

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Theofanis Tzatzakis, Konstantinos Papanikolaou, Dimitrios Draganidis, Panagiotis Tsimeas, Savvas Kritikos, Athanasios Poulios, Vasiliki C. Laschou, Chariklia K. Deli, Athanasios Chatzinikolaou, Alexios Batrakoulis, Georgios Basdekis, Magni Mohr, Peter Krustrup, Athanasios Z. Jamurtas and Ioannis G. Fatouros

:5. 7 Speed-endurance production training drills typically utilize repetitive soccer-specific, high-speed running (HSR) with powerful changes of direction. 8 These actions incorporate a strong eccentric component which is associated with exercise-induced muscle damage (EIMD). 9 EIMD produces localized

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Rebecca Quinlan and Jessica A. Hill

Participation in athletic training and competition can cause exercise-induced muscle damage. This phenomenon occurs as a result of mechanical and metabolic stress and is mainly associated with prolonged high-intensity eccentric or unaccustomed exercise. 1 Exercise-induced muscle damage is

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James Fell and Andrew Dafydd Williams

Recovery from exercise is integral to the physical training process. There is a perception among older athletes that aging negatively affects the recovery process. Plausible arguments for an impaired recovery with aging are a greater susceptibility of older muscle to exercise-induced skeletal-muscle damage and a slower repair and adaptation response. Differences in the physical activity level of the research participants are rarely considered, however. This makes it difficult to differentiate the respective roles of declining physical activity and aging on the recovery process. Furthermore, the type of exercise used to induce damage and monitor recovery is often not indicative of a normal training stimulus for athletes. This review discusses the effects of aging on skeletal-muscle damage and recovery processes and highlights the limitations of many of these studies with respect to older athletes. Future research should use an exercise intervention representative of a normal training stimulus and take the physical activity level of the participants into account.

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Richard J. Bloomer

The purpose of this study was to determine the effects of antioxidant therapy on indirect markers of muscle damage following eccentric exercise (EE). Eighteen women were randomized to an antioxidant supplement or a placebo before a bout of EE. Plasma creatine kinase (CK) activity, muscle soreness (MS), maximal isometric force (MIF), and range of motion (ROM) were assessed before and through 14 d postexercise. Eccentric exercise resulted in an increase in CK activity and MS, and a drop in MIF and ROM during the days following EE, which returned to baseline values 14 d after EE in both groups. Antioxidants attenuated the CK activity and MS response to the EE, while little difference was noted between groups in MIF or ROM. These fndings suggest that antioxidant supplementation was helpful in reducing the elevations in plasma CK activity and MS, with little impact on MIF and ROM loss.

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Michael J. Saunders

Endurance athletes commonly consume carbohydrate-electrolyte sports beverages during prolonged events. The benefits of this strategy are numerous—sports-beverage consumption during exercise can delay dehydration, maintain blood glucose levels, and potentially attenuate muscle glycogen depletion and central fatigue. Thus, it is generally agreed that carbohydrate-electrolyte beverages can improve endurance performance. A controversy has recently emerged regarding the potential role of protein in sports beverages. At least 3 recent studies have reported that carbohydrate-protein ingestion improves endurance performance to a greater extent than carbohydrate alone. In addition, carbohydrate-protein ingestion has been associated with reductions in markers of muscle damage and improved post exercise recovery. Although many of these muscle damage and recovery studies examined post exercise nutritional intake, recent evidence suggests that these benefits may be elicited with carbohydrate-protein consumption during exercise. These findings are intriguing and suggest that the importance of protein for endurance athletes has been underappreciated. However, 2 studies recently reported no differences in endurance performance between carbohydrate and carbohydrate-protein beverages. The varied outcomes may have been influenced by a number of methodological differences, including the amounts and types of carbohydrate or protein in the beverages, the exercise protocols, and the relative statistical power of the studies. In addition, although there are plausible mechanisms that could explain the ergogenic effects of carbohydrate-protein beverages, they remain relatively untested. This review examines the existing research regarding the efficacy of carbohydrate-protein consumption during endurance exercise. Limitations of the existing research are addressed, as well as potential areas for future study.