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Kadhiresan R. Murugappan, Michael N. Cocchi, Somnath Bose, Sara E. Neves, Charles H. Cook, Todd Sarge, Shahzad Shaefi and Akiva Leibowitz

failure in the setting of hemodynamic instability and multipressor shock. Empiric antibiotics and hydrocortisone were administered. The patient was diagnosed with severe exertional rhabdomyolysis with pigment-induced renal failure likely related to profound volume depletion. Despite the maximal supportive

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Beau Kjerulf Greer, John L. Woodard, Jim P. White, Eric M. Arguello and Emily M. Haymes

The purpose of this study was to determine whether branched-chain amino acid (BCAA) supplementation attenuates indirect indicators of muscle damage during endurance exercise as compared with an isocaloric, carbohydrate (CHO) beverage or a noncaloric placebo (PLAC) beverage. Nine untrained men performed three 90-min cycling bouts at 55% VO2peak. Subjects, blinded to beverage selection, ingested a total of 200 kcal of energy via the CHO or BCAA beverage before and at 60 min of exercise, or they drank the PLAC beverage. Creatine kinase (CK), lactate dehydrogenase (LDH), isokinetic leg-extension and fexion torque, and muscle soreness were assessed before and immediately, 4 h, 24 h, and 48 h post exercise. The trials were separated by 8 wk. CK activities were significantly lower after the BCAA trial than in the PLAC trial at 4, 24, and 48 h post exercise, as well as lower than the CHO beverage at 24 h post exercise. CK was lower in the CHO trial at the 24- and 48-h time points than in the PLAC trial. LDH activities were lower in the BCAA trial at 4 h than in the PLAC trial. As compared with the CHO and PLAC trials, ratings of perceived soreness were lower at 24 h post exercise, and leg-fexion torque was higher at the 48-h time point after the BCAA trial. The present data suggest that BCAA supplementation attenuates muscle damage during prolonged endurance exercise in untrained college-age men. CHO ingestion attenuates CK activities at 24 and 48 h post exercise as compared with a placebo beverage.

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Julio Cezar Q. Machado, Caroline M.O. Volpe, Leonardo S. Vasconcellos and José A. Nogueira-Machado

some situations, serum creatinine may be normal when the kidney function is committed (50%–60% already lost). The effect of physical exercises on renal function is really not known. It has been reported that strenuous exercise is associated with rhabdomyolysis and gastrointestinal problems. Lippi et

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Marco Van Brussel, Bart C. Bongers, Erik H.J. Hulzebos, Marcella Burghard and Tim Takken

of exercise explain risk of rhabdomyolysis in very long-chain Acyl-CoA dehydrogenase deficiency . PLoS ONE . 2016 ; 11 ( 2 ): 0147818 – 19 . PubMed ID: 26881790 doi:10.1371/journal.pone.0147818 10.1371/journal.pone.0147818 16. Dumitrescu D , Rosenkranz S . Graphical data display for

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Miguel A. Sanchez-Lastra, Vicente de Dios Álvarez and Carlos Ayán Pérez

; 72 : 40 – 47 . PubMed ID: 27666958 doi:10.1016/j.jsat.2016.09.002 41. MacDonald R , Rosner Z , Venters H . Case series of exercise-induced rhabdomyolysis in the New York City jail system . Am J Emerg Med . 2014 ; 32 ( 5 ): 466 – 467 . PubMed ID: 24655601 doi:10.1016/j.ajem.2013.08.051 42

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Eric S. Rawson, Mary P. Miles and D. Enette Larson-Meyer

might it work? Neurochemistry International, 89 , 249 – 259 . doi:10.1016/j.neuint.2015.08.010 10.1016/j.neuint.2015.08.010 Rawson , E.S. , Clarkson , P.M. , & Tarnopolsky , M.A. ( 2017 ). Perspectives on exertional rhabdomyolysis . Sports Medicine, 47 ( Suppl 1 ), 33 – 49 . PubMed doi

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Ronald J. Maughan, Louise M. Burke, Jiri Dvorak, D. Enette Larson-Meyer, Peter Peeling, Stuart M. Phillips, Eric S. Rawson, Neil P. Walsh, Ina Garthe, Hans Geyer, Romain Meeusen, Luc van Loon, Susan M. Shirreffs, Lawrence L. Spriet, Mark Stuart, Alan Vernec, Kevin Currell, Vidya M. Ali, Richard G.M. Budgett, Arne Ljungqvist, Margo Mountjoy, Yannis Pitsiladis, Torbjørn Soligard, Uğur Erdener and Lars Engebretsen

.08.010 10.1016/j.neuint.2015.08.010 Rawson , E.S. , Clarkson , P.M. , & Tarnopolsky , M.A. ( 2017 ). Perspectives on Exertional Rhabdomyolysis . Sports Medicine, 47 ( Suppl . 1 ), 33 – 49 . doi:10.1007/s40279-017-0689-z 10.1007/s40279-017-0689-z Rawson , E.S. , Miles , M.P. , & Larson