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Alon Eliakim, Ita Litmanovitz and Dan Nemet

bone strength in very low birth weight preterm infants: a randomized control trial . Calcif Tissue Int . 2016 ; 99 ( 3 ): 237 – 42 . PubMed doi:10.1007/s00223-016-0145-3 10.1007/s00223-016-0145-3 19. Littner Y , Mandel D , Mimouni FB , Dollberg S . Bone ultrasound velocity curves of newly

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Dorina Ianc, Carmen Serbescu, Marius Bembea, Laurent Benhamou, Eric Lespessailles and Daniel Courteix

We investigated the effects of calcium supplementation and physical practice on the bone ultrasound properties and trabecular microarchitecture in children. 160 children aged 8−11 were randomly allocated to active or nonactive groups and to receive either a calcium-phosphate or a placebo powder for 6 months. Skeletal status was assessed using an ultrasound technique, which measures the speed of sound (Ad-SoS, m/s) at the phalanx. Bone microarchitecture was characterized by fractal analysis measured on calcaneus radiographs and the result expressed as the Hmean parameter, that has been shown to a good reliability of the bone texture quality. After 6 months, the calcium group had significantly gained Ad-SoS compared to the placebo group (P = 0.01) and Hmean increase was greater in the active than the nonactive group (P < 0.05). Exercise and calcium supplementation had a differential effect on the bone tissue, calcium being rather linked to a systemic effect whereas exercise has acted better onto the skeletal stressed site.