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Panagiota Klentrou, Kirina Angrish, Nafisa Awadia, Nigel Kurgan, Rozalia Kouvelioti and Bareket Falk

–related proteins, such as LRP4, LRP5, and LRP6, and inhibits the canonical Wnt signaling pathway ( 15 , 19 , 42 ). Dickkopf-related protein 1 (DKK-1) is another catabolic osteokine produced by osteocytes ( 37 ), which inhibits the Wnt glycoproteins from attaching to the LRP5/6 receptor complex, thus leading to