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Jonathan M. Peake

Ascorbic acid or vitamin C is involved in a number of biochemical pathways that are important to exercise metabolism and the health of exercising individuals. This review reports the results of studies investigating the requirement for vitamin C with exercise on the basis of dietary vitamin C intakes, the response to supplementation and alterations in plasma, serum, and leukocyte ascorbic acid concentration following both acute exercise and regular training. The possible physiological significance of changes in ascorbic acid with exercise is also addressed. Exercise generally causes a transient increase in circulating ascorbic acid in the hours following exercise, but a decline below pre-exercise levels occurs in the days after prolonged exercise. These changes could be associated with increased exercise-induced oxidative stress. On the basis of alterations in the concentration of ascorbic acid within the blood, it remains unclear if regular exercise increases the metabolism of vitamin C. However, the similar dietary intakes and responses to supplementation between athletes and nonathletes suggest that regular exercise does not increase the requirement for vitamin C in athletes. Two novel hypotheses are put forward to explain recent findings of attenuated levels of cortisol postexercise following supplementation with high doses of vitamin C.

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Melinda M. Manore

This paper presents an overview of vitamin B6 and exercise, including the role that vitamin B6 plays in gluconeogenesis and glycogenolysis and changes in vitamin B6 metabolism during exercise. The dietary vitamin B6 intakes of athletes are also reviewed. Most studies report that male athletes have adequate dietary intakes of vitamin B6, whereas some females, especially those with low energy intakes, appear to have low vitamin B6 intakes. Few studies have assessed the vitamin B6 status of nonsupplementing athletes using the recommended status criteria. The role that vitamin B6 may play in attenuating the rise in plasma growth hormone observed during exercise is also reviewed. Finally, recomrnendations are given for further research in the area of vitamin B6 and exercise.

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Christopher C. Webster, Jeroen Swart, Timothy D. Noakes, and James A. Smith

. Webster CC , Noakes TD , Chacko SK , Swart J , Kohn TA , Smith JA . Gluconeogenesis during endurance exercise in cyclists habituated to a long-term low carbohydrate high-fat diet . J Physiol . 2016 ; 594 ( 15 ): 4389 – 4405 . PubMed ID: 26918583 doi:10.1113/JP271934 10.1113/JP271934

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Mark Glaister and Conor Gissane

balance between lactate production and clearance; with approximately 70% to 80% of the latter achieved through oxidation and the remainder by gluconeogenesis. 50 As such, the caffeine-induced increase in [BLa] determined in this meta-analysis could be due to either an increase in lactate production

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John Stoszkowski and Hans Amato

adrenaline are increased to mobilize fat from fat stores as a backup fuel and convert our muscle and organ tissue into glucose via gluconeogenesis, an inefficient and energetically wasteful process ( Veldhorst et al., 2009 ). Glucose is considered the obligatory energy substrate in the adult brain, with the

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Bruno P. Melo, Débora A. Guariglia, Rafael E. Pedro, Dennis A. Bertolini, Solange de Paula Ramos, Sidney B. Peres, and Solange M. Franzói de Moraes

potentiating gluconeogenesis, contributes to the energy metabolism. 13 On the other hand, chronically high cortisol concentrations at rest have been associated with physiological stress, immunosuppression, and homeostatic disturbance in several populations, including older adults with hypertension, diabetes

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Emma L. Sweeney, Daniel J. Peart, Irene Kyza, Thomas Harkes, Jason G. Ellis, and Ian H. Walshe

improvements in the late rather than total postprandial response after a bout of exercise. High-intensity exercise is known to temporarily increase glucose due to gluconeogenesis and possible carbohydrate sparing for glycogen repletion ( Marliss et al., 1992 ). It may be possible that as glucose regulation was

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Ralph Beneke, Tobias G.J. Weber, and Renate M. Leithäuser

mitochondrion for subsequent aerobic utilization. 25 , 26 Consequently, aerobic lactate oxidation reflects the ultimate reliance on carbohydrate (CHO) during exercise and prevents the option to use lactate/pyruvate as a substrate of gluconeogenesis. Aerobic lactate/pyruvate oxidation is defined by V ˙ O 2

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Louise M. Burke, John A. Hawley, Asker Jeukendrup, James P. Morton, Trent Stellingwerff, and Ronald J. Maughan

. • Cross-sectional study has shown that chronic K-LCHF adaptation does not alter gluconeogenesis or glycogen synthesis rates, but reduces glycogenolysis and glucose oxidation at rest and during exercise ( Webster et al., 2016 ). • Anecdotal reports and case history ( Webster et al., 2017 ) suggest that

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Enzo Hollville, Vincent Le Croller, Yoshihiro Hirasawa, Rémi Husson, Giuseppe Rabita, and Franck Brocherie

—including the brain—to be emphasized as an energy intermediate substrate for oxidation, gluconeogenesis, or glycogenesis. 31 Contrary to our hypothesis, passing skill performance did not mirror RSA performance decrement. Although the average number of balls played was not affected, our participants’ responses