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Hugo Ribeiro Zanetti, Lucas Gonçalves da Cruz, Camilo Luís Monteiro Lourenço, Giovana Castilho Ribeiro, Marco Aurélio Ferreira de Jesus Leite, Fernando Freitas Neves, Mário Leon Silva-Vergara and Edmar Lacerda Mendes


Highly active antiretroviral therapy (HAART) is associated with high total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c), triglyceride (TG), and C-reactive protein (CRP) levels. The natural course of the HIV infection reduces the high-density lipoprotein level (HDL-c). Thus, physical exercise plays a key role in reducing the effects of HAART and HIV.


Thirty people living with HIV (PLHIV) were randomized to the nonlinear resistance training (NLRT) and control (CON) groups. The NLRT group underwent 12 weeks of resistance training, whereas the CON group maintained usual daily activities. All volunteers underwent anthropometric, body composition, and biochemical assessments at the beginning and end of 12 weeks.


After 12 weeks, the NLRT group had increased lean body mass (P < .0001), and a reduction in body fat mass (P < .0001) and body fat percentage (P < .0001). The levels of TC (P < .0001), LDL-c (P = .049), TG (P < .0001), and CRP (P = .004) were reduced, and the HDL-c level increased (P < .0001).


Twelve weeks of NLRT causes beneficial changes in the body composition, lipid profile, and inflammation markers in PLHIV, and it can be used in this patient population.

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Luiz Rodrigo Augustemak de Lima, Diego Augusto Santos Silva, Kelly Samara da Silva, Andreia Pelegrini, Isabela de Carlos Back and Edio Luiz Petroski


To examine aerobic fitness, total moderate to vigorous physical activity (MVPA) and also patterns in terms of MVPA between children and adolescents with human immunodeficiency virus (HIV) and controls, and to determine whether differences, if any, are associated with HIV, sex and highly active antiretroviral therapy (HAART).


A cross-sectional analysis was carried out with 130 children and adolescents, aged between 8 and 15 years, divided into two groups (HIV group= 65 patients, control group= 65 healthy participants). Total MVPA was measured by accelerometers and 5 and 10-min bouts were estimated. The peak oxygen uptake (peak VO2) was measured by breath-by-breath respiratory exchange in an incremental cycle ergometer test.


HIV-positive participants had lower peak VO2 (39.2 ± 6.8 vs. 44.5 ± 9.1, lower bouts of MVPA of 5-min (19.7 ± 16.6 vs. 26.6 ± 23.5) and 10-min (3.6 ± 3.9 vs. 5.8 ± 7.2), but similar total MVPA (49.5 ± 28.9 vs. 49.1 ± 30.6 HIV infection in untreated, nonprotease inhibitors (PI)- based HAART and PI-based HAART patients was associated with lower 8.5 (95%CI= 12.5–4.6), 7.1 (95%CI= 10.6–3.6) and 4.5 (95%CI= 7.0–2.0) of peak VO2.


Children and adolescents with HIV demonstrated lower aerobic fitness compared with the controls and the absence of HAART may increase peak VO2 impairment. Lower bouts of MVPA were also observed in HIV group despite the similar values of total MVPA of controls.

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Bruno G.G. da Costa, Kelly S. da Silva, Rafael M. da Costa, Edio L. Petroski, Isabela C. Back, Paulo H.A. Guerra and Luiz R.A. de Lima

highly active antiretroviral therapy (HAART) and protease-based HAART (PI-based HAART). These patients commonly present metabolic, inflammatory, and cardiovascular abnormalities ( 2 , 13 ) that impact their overall health, and their engagement in physical activity compared with their healthy peers may be

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Bindu P. Gopalan, Mary Dias, Karthika Arumugam, Reena R. D’Souza, Mathew Perumpil, Prasanna Kulkarni, Udaykumar Ranga and Anita Shet

, Ukibe NR . The effects of highly active antiretroviral therapy on the serum levels of pro-inflammatory and anti-inflammatory cytokines in HIV infected subjects . J Biomed Sci . 2018 ; 25 ( 1 ): 88 . PubMed ID: 30501642 doi: 10.1186/s12929-018-0490-9 30501642 35. Pedro RE , Candido N

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Sanaz Nosrat, James W. Whitworth, Nicholas J. SantaBarbara, Shira I. Dunsiger and Joseph T. Ciccolo

. , Bartoli , L. , . . . Starace , F. ( 2004 ). Depressive symptoms, neurocognitive impairment, and adherence to highly active antiretroviral therapy among HIV-infected persons . Psychosomatics, 45 ( 5 ), 394 – 402 . PubMed ID: 15345784 doi:10.1176/appi.psy.45.5.394 10.1176/appi.psy.45.5.394 Arent