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Sanaz Nosrat, James W. Whitworth, Nicholas J. SantaBarbara, Shira I. Dunsiger and Joseph T. Ciccolo

In the United States, the Centers for Disease Control and Prevention has estimated that there are currently 1.1 million people living with human immunodeficiency virus (HIV), including 14% who are unaware of their infection ( Centers for Disease Control and Prevention, 2019 ). Among these, Black

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Luiz Rodrigo Augustemak de Lima, Diego Augusto Santos Silva, Kelly Samara da Silva, Andreia Pelegrini, Isabela de Carlos Back and Edio Luiz Petroski

Purpose:

To examine aerobic fitness, total moderate to vigorous physical activity (MVPA) and also patterns in terms of MVPA between children and adolescents with human immunodeficiency virus (HIV) and controls, and to determine whether differences, if any, are associated with HIV, sex and highly active antiretroviral therapy (HAART).

Method:

A cross-sectional analysis was carried out with 130 children and adolescents, aged between 8 and 15 years, divided into two groups (HIV group= 65 patients, control group= 65 healthy participants). Total MVPA was measured by accelerometers and 5 and 10-min bouts were estimated. The peak oxygen uptake (peak VO2) was measured by breath-by-breath respiratory exchange in an incremental cycle ergometer test.

Results:

HIV-positive participants had lower peak VO2 (39.2 ± 6.8 vs. 44.5 ± 9.1 ml.kg-1min-1), lower bouts of MVPA of 5-min (19.7 ± 16.6 vs. 26.6 ± 23.5) and 10-min (3.6 ± 3.9 vs. 5.8 ± 7.2), but similar total MVPA (49.5 ± 28.9 vs. 49.1 ± 30.6 min.day-1). HIV infection in untreated, nonprotease inhibitors (PI)- based HAART and PI-based HAART patients was associated with lower 8.5 (95%CI= 12.5–4.6), 7.1 (95%CI= 10.6–3.6) and 4.5 (95%CI= 7.0–2.0) ml.kg-1min-1 of peak VO2.

Conclusion:

Children and adolescents with HIV demonstrated lower aerobic fitness compared with the controls and the absence of HAART may increase peak VO2 impairment. Lower bouts of MVPA were also observed in HIV group despite the similar values of total MVPA of controls.

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Meghan K. Edwards and Paul D. Loprinzi

beneficial effects of muscular strength improvements have also been shown to extend to adults with human immunodeficiency virus 23 and Parkinson’s disease. 24 Of additional note, recent work demonstrates a direct association between lower extremity muscle strength and leukocyte telomere length, with

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Zachary K. Winkelmann, Ethan J. Roberts and Kenneth E. Games

participants were white (n = 27; 90%) and were self-reported right leg dominant (n = 25; 83.3%). Participants were excluded if they had a previous lower-extremity injury in the past 3 months, AIDS or human immunodeficiency virus, acute infection, active tuberculosis, erysipelas, malignant diseases, heart