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Christopher C. Webster, Kathryn M. van Boom, Nur Armino, Kate Larmuth, Timothy D. Noakes, James A. Smith and Tertius A. Kohn

. Insulin receptor substrate 1 (IRS1) and glucose transporter 4 (GLUT4) are key proteins in the insulin signaling pathway of skeletal muscle. The binding of insulin to the insulin receptor results in IRS1 phosphorylation, which initiates a signaling cascade and GLUT4 translocation to the membrane and the

Open access

Emma L. Sweeney, Daniel J. Peart, Irene Kyza, Thomas Harkes, Jason G. Ellis and Ian H. Walshe

peripheral insulin signaling, with five nights of SR reducing peripheral, but not hepatic, insulin sensitivity ( Rao et al., 2015 ). Furthermore, SR reduces Akt phosphorylation, which plays a key role in the insulin signaling pathway in peripheral tissues ( Broussard et al., 2012 ). We hypothesized that a

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Alexandre M. Lehnen, Graziela H. Pinto, Júlia Borges, Melissa M. Markoski and Beatriz D. Schaan

mechanisms, but rather the insulin-dependent pathway. Also, cardiac tissue is more susceptible to adaptations involving GLUT4 content and insulin-signaling pathways compared with the gastrocnemius muscle. The clinical implications of our results arise from the renewal of benefits within a short timeframe