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Brianna J. Stubbs, Pete J. Cox, Tom Kirk, Rhys D. Evans and Kieran Clarke

–e) Schematic showing protocol for all studies. KME = ketone monoester; KS = ketone salt; βHB = beta-hydroxybutyrate. Using ketone drinks to achieve “fed ketosis” may improve athletic performance and recovery. Early studies indicate that a ketone monoester (KME; R -3-hydroxybutyl- R -1,3-hydroxybutyrate) may improve

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Hunter S. Waldman, Brandon D. Shepherd, Brendan Egan and Matthew J. McAllister

ester forms, it is specifically the (R)-3-hydroxybutyl (R)-3-hydroxybutyrate ketone monoester (KME) that produces dramatically higher plasma D -β-OHB concentrations (1.0–6.0 mM; Cox et al., 2016 ; Evans & Egan, 2018 ; Holdsworth et al., 2017 ). Inducing a state of nutritional ketosis (plasma D -β