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Clarice Martins, Ismael Freitas Jr., Andréia Pizarro, Luísa Aires, Gustavo Silva, Maria Paula Santos and Jorge Mota

Nonalcoholic fatty liver disease (NAFLD) is one of the most frequent complications associated with excess adiposity. Its pathogenesis is complex and there are multiple factors that may contribute to it. AIM: To analyze whether cardiorespiratory fitness (CRF), waist circumference (WC), and C-reactive protein (CRP) are associated with alanine aminotransferase (ALT) in children with obesity. METHODS: 79 overweight/obese children of both genders, 11–13 year-olds, with abnormal serum ALT from Porto public schools comprised the sample. Measurements included CRF (20-m Shuttle Run Test), WC (NHANES protocol), CRP and ALT (Cholestech LDX analyzer). Logistic regression adjusted for gender, maturation, and weight with ALT levels as dependent variable (risk vs. non risk), and WC (risk vs. non risk), CRP (risk vs. non risk), and CRF (fit vs. unfit) as independent variables. Level of significance was set at 95%. RESULTS: Logistic regression showed that obese fit children were less likely to have abnormal ALT values (OR=.031) CONCLUSION: In obese children, higher cardiovascular fitness appears to reduce the chance of decreased liver function.

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David L. Mayhew, Jerry L. Mayhew and John S. Ware

The purpose of this study was to determine the effect of long-term Cr supplementation on blood parameters reflecting liver and kidney function. Twenty-three members of an NCAA Division II American football team (ages = 19–24 years) with at least 2 years of strength training experience were divided into a Cr monohydrate group (CrM, n = 10) in which they voluntarily and spontaneously ingested creatine, and a control group (n = 13) in which they took no supplements. Individuals in the CrM group averaged regular daily consumption of 5 to 20 g (mean ± SD = 13.9 ± 5.8 g) for 0.25 to 5.6 years (2.9 ± 1.8 years). Venous blood analysis for serum albumin, alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, bilirubin, urea, and creatinine produced no significant differences between groups. Creatinine clearance was estimated from serum creatinine and was not significantly different between groups. Within the CrM group, correlations between all blood parameters and either daily dosage or duration of supplementation were nonsignificant. Therefore, it appears that oral supplementation with CrM has no long-term detrimental effects on kidney or liver functions in highly trained college athletes in the absence of other nutritional supplements.

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Wayne W. Campbell, Lyndon J.O. Joseph, Richard E. Ostlund Jr., Richard A. Anderson, Peter A. Farrell and William J. Evans

This study assessed the effects of resistive training (RT) with or without chromium picolinate (Cr-pic) supplementation on the 24-h urinary excretions of myo-inositol, D-chiro-inositol, and pinitol, as well as clinical indices of kidney and liver functions. Thirty-two nondiabetic subjects, age 62 ± 4 y, performed RT twice weekly for 12 wk and consumed either 924 μg Cr/d as Cr-pic (n = 17) or a placebo (n = 15). Whole-body strength increased in all subjects by 20% and urinary chromium excretion increased 47-fold in the Cr-pic group. Urinary myo-inositol, D-chiro-inositol, and pinitol were not changed with RT or influenced by Cr-pic. Serum indices of kidney and liver functions were within clinically normal ranges at baseline and the end of the study. These results suggest that RT did not influence the urinary excretions of inositols. High dose Cr-pic did not influence the urinary excretion of inositols and the selected indices of kidney and liver functions in conjunction with RT

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Dietrich Rothenbacher, Dhayana Dallmeier, Michael D. Denkinger, Bernhard O. Boehm, Wolfgang Koenig, Jochen Klenk and ActiFE Study Group

diabetes, smoking, an inflammatory marker, and a marker for liver function. This relationship, however, was attenuated and no longer evident when also adjusting for BMI. Therefore, BMI seems among the determinants of SHBG and a possible mediator of SHBG levels. Body fat and body composition are major

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George Wilson, Dan Martin, James P. Morton and Graeme L. Close

-being . Sports Medicine, 44 ( 6 ), 785 – 796 . PubMed ID: 24682950 doi:10.1007/s40279-014-0169-7 10.1007/s40279-014-0169-7 Wilson , G. , Fraser , W.D. , Sharma , A. , Eubank , M. , Drust , B. , Morton , J.P. , & Close , G.L. ( 2013a ). Markers of bone health, renal function, liver function

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Andreas M. Kasper, Ben Crighton, Carl Langan-Evans, Philip Riley, Asheesh Sharma, Graeme L. Close and James P. Morton

. , Eubank , M. , Drust , B. , Morton , J.P. , & Close , G.L. ( 2013 ). Markers of bone health, renal function, liver function, anthropometry and perception of mood: A comparison between flat and National Hunt Jockeys . International Journal of Sports Medicine, 34 , 453 – 459 . PubMed ID

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Blair Crewther, Konrad Witek, Paweł Draga, Piotr Zmijewski and Zbigniew Obmiński

found with DAA supplementation, nor any differences from the placebo treatment. This suggests that DAA has no apparent side effects on kidney and liver functioning when taken by healthy men at the recommended dosage for a short period. On a subjective level, the athletes tested did not report any

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Daniel Martin, Craig Sale, Simon B. Cooper and Kirsty J. Elliott-Sale

liver function 1 0.5 Effect on training/performance 2 0.9 Bloating 1 0.5 Reduced bloating 1 0.5 Hormone imbalance 1 0.5 Improved bone density 1 0.5 Increased appetite 1 0.5 Less faint 1 0.5 Stomach pain 1 0.5 Reduced fluctuations in water retention 1 0.5 Unspecified pain 1 0.5 Reduced fluctuations in

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Amy J. Hector and Stuart M. Phillips

not have detrimental effects on health, including kidney function ( Longland et al., 2016 ), bone health ( Shams-White et al., 2017 ), or liver function and blood lipids ( Antonio et al., 2016a , 2016b ). Weight Loss Supplements: Beyond Protein and Amino Acid Derivatives The primary driver of weight

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Louise M. Burke, Graeme L. Close, Bronwen Lundy, Martin Mooses, James P. Morton and Adam S. Tenforde

. , Morton , J.P. , & Close , G.L. ( 2013a ). Markers of bone health, renal function, liver function, anthropometry and perception of mood: A comparison between Flat and National Hunt Jockeys . International Journal of Sports Medicine, 34 ( 5 ), 453 – 459 . doi:10.1055/s-0032-1321898 Wilson , G