equivocal, some studies have found that NSAIDs hamper mixed muscle protein and collagen synthesis ( Dideriksen, 2014 ; Trappe et al., 2002 ). Other common self-medications, such as alcohol, have been shown to reduce the activation of the mechanistic target of rapamycin complex 1 (mTORC1) in model organisms
Search Results
Cannabidiol Does Not Impair Anabolic Signaling Following Eccentric Contractions in Rats
Henning T. Langer, Agata A. Mossakowski, Suraj Pathak, Mark Mascal, and Keith Baar
The Effect of Carbohydrate Ingestion Following Eccentric Resistance Exercise on AKT/mTOR and ERK Pathways: A Randomized, Double-Blinded, Crossover Study
Vandre C. Figueiredo, Michelle M. Farnfield, Megan L.R. Ross, Petra Gran, Shona L. Halson, Jonathan M. Peake, David Cameron-Smith, and James F. Markworth
al., 2000 ; Tipton et al., 1999 ). The anabolic response derived from the amino acid ingestion can be explained by the effect of branched-chain amino acids (e.g., leucine) to enhance rates of translation via activation of the mammalian target of rapamycin complex 1 (mTORC1) ( Dreyer et al., 2008 ; Moberg
Effect of Protein Supplementation Combined With Resistance Training in Gait Speed in Older Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Juan Li, Yahai Wang, Fang Liu, and Yu Miao
hypertrophy and improve skeletal muscle function ( Campbell & Leidy, 2007 ). Protein supplementation as well as RT, independent of each other, stimulates the mammalian target of the rapamycin complex 1 (mTORC1) pathway ( Burd et al., 2013 ; Carbone et al., 2012 ). Proteins (mainly leucine) enter myocytes by
Whey Protein Augments Leucinemia and Postexercise p70S6K1 Activity Compared With a Hydrolyzed Collagen Blend When in Recovery From Training With Low Carbohydrate Availability
Samuel G. Impey, Kelly M. Hammond, Robert Naughton, Carl Langan-Evans, Sam O. Shepherd, Adam P. Sharples, Jessica Cegielski, Kenneth Smith, Stewart Jeromson, David L. Hamilton, Graeme L. Close, and James P. Morton
and PKB signaling or (b) a direct effect of increased fat availability ( Kimball et al., 2015 ) and/or reduced glycogen-mediating suppression of mTORC1 complex via energetic stress-related mechanisms. The present data lend support for the latter mechanism for several reasons. First, we observed that
No Difference Between the Effects of Supplementing With Soy Protein Versus Animal Protein on Gains in Muscle Mass and Strength in Response to Resistance Exercise
Mark Messina, Heidi Lynch, Jared M. Dickinson, and Katharine E. Reed
al., 2009 ). Leucine, one of the three branched-chain amino acids, has been extensively investigated for its ability to activate MPS. In particular, leucine activates MPS through the mTOR complex 1 (mTORC1) ( Anthony et al., 2000 ) and possibly also through an mTORC1-independent process ( Bolster et
A Little Pepper-Upper? Systematic Review of Randomized Controlled Studies on Capsaicinoids, Capsinoids, and Exercise Performance
Betül Sukan-Karaçağıl, Gamze Akbulut, Yasemin Açar, and Meleknur Demirkoparan
ribosomal biogenesis. This indicates that endurance exercise performance mostly depends on adenosine monophosphate-activated protein kinase (AMPK) activity, while resistance exercises depend on mammalian target of rapamycin complex 1 (mTORC1) activity. AMPK activity is dependent on energy sources (glucose
Dose-Response Relationship of Weekly Resistance-Training Volume and Frequency on Muscular Adaptations in Trained Men
Samuel R. Heaselgrave, Joe Blacker, Benoit Smeuninx, James McKendry, and Leigh Breen
28 weekly sets, in trained individuals. From a mechanistic perspective, although a number of acute studies have reported associations between mechanistic target of rapamycin complex 1 (mTORC1)–mediated signaling/MPS and RT volume at ≤9 weekly sets, 27 , 28 there is evidence of a plateau in this
Blood Flow Restriction Training for the Rotator Cuff: A Randomized Controlled Trial
Jason Brumitt, Marcey Keefer Hutchison, Dan Kang, Zach Klemmer, Mike Stroud, Edward Cheng, Neil Patrick Cayanan, and Sheldon Shishido
.3806/ijktr.1.6 9. Fry CS , Glynn EL , Drummond MJ , et al . Blood flow restriction exercise stimulates mTORC1 signaling and muscle protein synthesis in older men . J Appl Physiol . 2010 ; 108 ( 5 ): 1199 – 1209 . PubMed ID: 20150565 doi:10.1152/japplphysiol.01266.2009 20150565 10. Gunderman DM
Gastrointestinal Effects of Exogenous Ketone Drinks are Infrequent, Mild, and Vary According to Ketone Compound and Dose
Brianna J. Stubbs, Pete J. Cox, Tom Kirk, Rhys D. Evans, and Kieran Clarke
promotes mTORC1 signaling but not glycogen resynthesis in human muscle . Frontiers in Physiology, 8 , 310 . doi:10.3389/fphys.2017.00310 10.3389/fphys.2017.00310 Waldman , H.S. , Basham , S.A. , Price , F.G. , Smith , J.W. , Chander , H. , Knight , A.C. , . . . McAllister , M.J. ( 2018
Blood-Flow-Restriction Training: Validity of Pulse Oximetry to Assess Arterial Occlusion Pressure
Zhen Zeng, Christoph Centner, Albert Gollhofer, and Daniel König
al . Blood flow restriction exercise stimulates mTORC1 signaling and muscle protein synthesis in older men . J Appl Physiol . 2010 ; 108 ( 5 ): 1199 – 1209 . doi:10.1152/japplphysiol.01266.2009 10.1152/japplphysiol.01266.2009 20150565 19. Clarkson MJ , Fraser SF , Bennett PN , McMahon LP
